{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:40:03Z","timestamp":1788795603943,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:00:00Z","timestamp":1724112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sickle cell disease is a rare genetic disease resulting from an abnormality in hemoglobin. Hemostasis in the steady state, defined as \u22652 months without vaso\u2010occlusive crises, is poorly described in the literature. We report the routine hemostasis profile in steady state patients with sickle cell disease (SCD), including during pregnancy and according to phenotype. This retrospective study collected data over the period 2010 to 2021. Data on routine hemostasis parameters (prothrombin time [PT] activated partial thromboplastin time [aPTT], and platelets) were collected from medical records and were compared with laboratory norms including during pregnancy; the HbSS phenotype was compared with the HbSC, HbSB\u00b0thalassemia, and HbSB+thalassemia phenotypes. we included 119 adults (representing 190 day\u2010hospitals) with SCD who had attended at least one checkup in the steady state. Seven patients (15 day\u2010hospitals) on anticoagulants were excluded. Eleven (17 day\u2010hospitals) were pregnant. Mean routine hemostasis parameters were within normal values regardless of pregnancy. Mean PT was lower during pregnancy (12.3\u00a0\u00b1\u00a00.6 s vs. 13.2\u00a0\u00b1\u00a01.0 s; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.01). PT and platelet counts were higher (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.01) and aPTT was lower (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.03) in men and nonpregnant women in the HbSS group compared with those in the HbSC group. routinely collected hemostasis parameters in steady state patients were within normal laboratory values, including in pregnant women. PT values differed significantly between pregnant women and nonpregnant women, and PT, aPTT, and platelet counts differed between HbSS, HbSC, and HbSB+thalassemia phenotypes.<\/jats:p>","DOI":"10.1002\/jha2.876","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T02:51:55Z","timestamp":1724295115000},"page":"920-928","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Routine hemostasis profile in steady state sickle cell disease adult patients compared to laboratory values, between phenotypes and during pregnancy: A retrospective, descriptive study"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3852-7382","authenticated-orcid":false,"given":"Comlan","family":"Affo","sequence":"first","affiliation":[{"name":"Service de M\u00e9decine Interne H\u00f4pital Louis Mourier, AP\u2010HP  Colombes France"},{"name":"Universit\u00e9 Paris Cit\u00e9  Paris 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