{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T05:55:49Z","timestamp":1788155749201,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lenalidomide maintenance (LM) has shown benefit in progression\u2010free survival (PFS) and overall survival (OS) in clinical trials. LM is the recommended standard of care in patients with newly diagnosed multiple myeloma (MM) after high\u2010dose melphalan and autologous stem cell transplantation (HDM\u2010ASCT). In Denmark, LM has been approved and publicly funded for all patients treated with HDM\u2010ASCT since June 2019. Patients with newly diagnosed MM treated with their first HDM\u2010ASCT between June 2019 and March 2022 were included and followed until data cut\u2010off in June 2023. To compare outcomes, a historical pre\u2010LM cohort from the Danish MM Registry, consisting of 364\u00a0MM patients treated with HDM\u2010ASCT between June 2015 and June 2019, was used. Among 364 patients treated with HDM\u2010ASCT after June 2019, 22.3% received consolidation therapy and 3.7% underwent tandem HDM\u2010ASCT. During follow\u2010up, 297 patients (81.6%) initiated maintenance therapy, with 277 (76.1%) receiving LM. Overall, 145 patients (52.3%) discontinued LM most commonly due to toxicity 75 (51.7%), with fatigue (30.7%), cytopenia (25.3%), and neuropathy (17.3%) being the main reasons. In a 6\u2010month landmark analysis, early discontinuation did not negatively impact PFS or OS. The LM cohort had similar PFS, and OS compared to the pre\u2010LM cohort. The 3\u2010year PFS and OS rates in the LM cohort were 61% and 86%, respectively, while the pre\u2010LM cohort had a 3\u2010year PFS of 55% and a 3\u2010year OS of 89%. In conclusion, the introduction of LM as a nationwide treatment option in Denmark did not lead to improved clinical outcomes.<\/jats:p>","DOI":"10.1002\/jha2.881","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T09:33:57Z","timestamp":1711532037000},"page":"316-324","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Nationwide implementation of lenalidomide maintenance in multiple myeloma: A retrospective, real\u2010world study"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8599-4803","authenticated-orcid":false,"given":"Mads","family":"Harsl\u00f8f","sequence":"first","affiliation":[{"name":"Department of Hematology Rigshospitalet  Copenhagen Denmark"},{"name":"Biotech Research and Innovation Centre University of Copenhagen  Kobenhavn 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