{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T07:05:49Z","timestamp":1778396749681,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Multiple myeloma remains an incurable cancer mostly affecting older adults and is characterized by a series of remission inductions and relapses. This study aims to evaluate the outcomes in newly diagnosed transplant\u2010ineligible patients using bortezomib\/lenalidomide\u2010based regimens in the Canadian real world as well as their outcomes in the second line. The Canadian Myeloma Research Group Database (CMRG\u2010DB) is a national database with input from multiple Canadian Centres with now up to 8000 patients entered. A total of 1980 transplant ineligible patients were identified in the CMRG\u2010DB between the years of 2007\u20132021. The four most commonly used induction regimens are bortezomib\/melphalan\/prednisone (VMP) (23%), cyclophosphamide\/bortezomib\/dexamethasone (CyBorD) (47%), lenalidomide\/dexamethasone (Rd) (24%), and bortezomib\/lenalidomide\/dexamethasone (VRd) (6%). After a median follow\u2010up of 30.46 months (0.89\u2013168.42), the median progression\u2010free survival (mPFS) and median overall survival (mOS) of each cohort are 23.5, 22.9, 34.0 months, and not reached (NR) and 64.1, 51.1, 61.5 months, and NR respectively. At the time of data cut\u2010off, 1128 patients had gone on to second\u2010line therapy. The mPFS2 based on first\u2010line therapy, VMP, CyBorD, Rd, and VRd is 53.3, 48.4, 62.7 months, and NR respectively. The most common second\u2010line regimens are Rd (47.4%), DRd (12.9%), CyBorD (10.3%), and RVd (8.9%) with a mPFS and a mOS of 17.0, 31.1, 15.4, and 14.0 months and 34.7, NR, 47.6, 33.4 months, respectively. This study represents the real\u2010world outcomes in newly diagnosed transplant\u2010ineligible myeloma patients in Canada. The spectra of therapy presented here reflect the regimens still widely used around the world. While this is sure to change with anti\u2010CD38 monoclonal antibodies now reflecting a new standard of care in frontline therapy, this cohort is reflective of the type of multiple myeloma patient currently experiencing relapse in the real\u2010world setting.<\/jats:p>","DOI":"10.1002\/jha2.894","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T11:09:23Z","timestamp":1714388963000},"page":"474-484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Long\u2010term follow\u2010up of outcomes including progression\u2010free survival 2 in patients with transplant\u2010ineligible multiple myeloma in the real\u2010world practice: A multi\u2010institutional report from the Canadian Myeloma Research Group (CMRG) database"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8556-4926","authenticated-orcid":false,"given":"Rayan","family":"Kaedbey","sequence":"first","affiliation":[{"name":"Division of Hematology, Department of Medicine Jewish General Hospital Montreal Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna","family":"Reece","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Hematology Princess Margaret Cancer Centre Toronto Canada"},{"name":"Canadian Myeloma Research Group  Vaughan Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher P.","family":"Venner","sequence":"additional","affiliation":[{"name":"Department of Hematology Lymphoma and Myeloma Program, BC Cancer, Vancouver Centre Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arleigh","family":"McCurdy","sequence":"additional","affiliation":[{"name":"Department of Medicine The Ottawa Hospital  Ottawa Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiandong","family":"Su","sequence":"additional","affiliation":[{"name":"Canadian Myeloma Research Group  Vaughan Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Medicine Cross Cancer Institute  Edmonton Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha","family":"Louzada","sequence":"additional","affiliation":[{"name":"Department of Medicine London Regional Cancer Center  London Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9294-9437","authenticated-orcid":false,"given":"Victor H","family":"Jimenez\u2010Zepeda","sequence":"additional","affiliation":[{"name":"Department of Medicine Arnie Charbonneau Cancer Institute, University of Calgary Calgary Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1584-1067","authenticated-orcid":false,"given":"Hira","family":"Mian","sequence":"additional","affiliation":[{"name":"Department of Medicine Juravinski Cancer Center Hamilton Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Medicine BC Cancer Agency, Vancouver General Hospital Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Sebag","sequence":"additional","affiliation":[{"name":"Department of Medicine McGill University  Montreal Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Stakiw","sequence":"additional","affiliation":[{"name":"Department of Medicine Saskatoon Cancer Centre, University of Saskatchewan Saskatoon Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darrell","family":"White","sequence":"additional","affiliation":[{"name":"Division of Hematology Queen Elizabeth II Health Sciences Centre. 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