{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:44:25Z","timestamp":1790228665968,"version":"4.1.0"},"reference-count":5,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 34\u2010year\u2010old woman received umbilical cord blood transplantation for refractory T\u2010cell prolymphocytic leukemia after salvage therapy with alemtuzumab. She developed right angular cheilitis on the 46th day after transplantation, which worsened after receiving systemic steroid therapy for extensive chronic graft versus host disease. The treatment dosage of acyclovir (ACV), ganciclovir, and vidarabine ointment was not effective due to ACV\u2010resistant mutations of the herpes simplex virus type 1 (HSV\u20101) in the thymidine kinase domain. Foscarnet is expected to be effective against ACV\u2010resistant HSV\u20101 infection. However, it could not be used because the patient developed renal dysfunction. Several viral thymidine kinase mutations related to ACV resistance were found in the patient's sample. Nevertheless, amenamevir, a helicase\u2010primase complex inhibitor, was effective in our patient who was significantly immunocompromised after allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT). ACV\u2010resistant HSV infection after allo\u2010HSCT is an rare but important complication in the era of low\u2010dose long\u2010term ACV prophylaxis. To date, there is no established treatment against ACV\u2010resistant HSV infection. This case report showed that amenamevir could be a promising treatment option for ACV\u2010resistant HSV infection in patients with renal failure after allo\u2010HSCT.<\/jats:p>","DOI":"10.1002\/jha2.899","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T11:03:15Z","timestamp":1714388595000},"page":"616-619","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Successful treatment of acyclovir\u2010resistant herpes simplex virus infection with amenamevir in a patient who received umbilical cord blood transplantation for T\u2010cell prolymphocytic leukemia"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8864-6933","authenticated-orcid":false,"given":"Yuma","family":"Kawamura","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology Konan Kosei Hospital  Konan 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Hematology and Oncology Konan Kosei Hospital  Konan Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuaki","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Konan Kosei Hospital  Konan Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Kohno","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Konan Kosei Hospital  Konan Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souichi","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Virology 1 National Institute of Infectious Diseases  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Fukui","sequence":"additional","affiliation":[{"name":"Department of Virology 1 National Institute of Infectious Diseases  Tokyo 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