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Considering that various circRNAs have a strong potential as molecular biomarkers, we aimed to investigate the expression of ciRS\u20107 in plasma cell disorders, assess its prognostic importance in MM, and compare these findings with those of individuals with smoldering MM (SMM) and monoclonal gammopathy of unknown significance (MGUS). This study included 171 patients (110 newly diagnosed MM, 34 SMM, and 27 MGUS cases), from which bone marrow aspirate samples were collected for CD138+ plasma cell selection. Total RNA was reversely transcribed using random hexamer primers, and the expression levels of ciRS\u20107 were quantified using an in\u2010house\u2010developed protocol that includes pre\u2010amplification and real\u2010time quantitative polymerase chain reaction. ciRS\u20107 levels were found to significantly differ among CD138+ plasma cells of MM, SMM, and MGUS patients. ROC analysis indicated that ciRS\u20107 expression effectively distinguishes between MM and SMM patients. Moreover, high levels of ciRS\u20107 were associated with unfavorable prognosis in MM, independently of MM patients\u2019 age and Revised International Staging System stage. Additionally, in silico analysis predicted the binding of 85 microRNAs to ciRS\u20107. In conclusion, this study provides novel insights into the role of ciRS\u20107 as a promising molecular marker able to distinguish MM from SMM and predict prognosis in MM.<\/jats:p>","DOI":"10.1002\/jha2.903","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T01:44:27Z","timestamp":1717638267000},"page":"677-689","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["ciRS\u20107 circular RNA overexpression in plasma cells is a promising molecular biomarker of unfavorable prognosis in multiple myeloma"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0227-9258","authenticated-orcid":false,"given":"Maria","family":"Papatsirou","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Faculty of Biology National and Kapodistrian University of Athens  Athens 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