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We demonstrate a 5\u2010year overall survival (OS) of 73% and progression\u2010free survival (PFS) of 52% for all 50 patients with a median follow\u2010up of 61.3 months. For the 35 transplanted patients, calculated from the date of ASCT, the 5\u2010year OS and PFS were 91% and 68%, respectively. After ASCT, the rate of organ response improved over time but stabilized around 3 years. A complete cardiac response was seen in around 60% of patients and remained stable from 2 years onward. Reaching complete renal response was slower over time and achieved by 61% of the renal\u2010affected patients at 5 years. We confirm the excellent outcomes after ASCT and demonstrate a 60% complete organ response with longer follow\u2010up.<\/jats:p>","DOI":"10.1002\/jha2.918","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T04:29:48Z","timestamp":1718598588000},"page":"815-819","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["HOVON 104, long\u2010term follow\u2010up of bortezomib\u2010dexamethasone induction therapy followed by autologous stem cell transplantation in newly diagnosed AL amyloidosis patients"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3139-8379","authenticated-orcid":false,"given":"Monique C.","family":"Minnema","sequence":"first","affiliation":[{"name":"Department of Hematology UMC Utrecht University Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5666-5015","authenticated-orcid":false,"given":"Kazem","family":"Nasserinejad","sequence":"additional","affiliation":[{"name":"Department of Hematology HOVON Data Center Erasmus MC Cancer Institute  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1917-6746","authenticated-orcid":false,"given":"Ute","family":"Hegenbart","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Amyloidosis Center University Hospital Heidelberg  Heidelberg The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1250-7979","authenticated-orcid":false,"given":"Paula F.","family":"Ypma","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Haga Hospital  Den Haag The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6042-978X","authenticated-orcid":false,"given":"Ka Lung","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Hematology Ziekenhuis Netwerk Antwerpen Stuivenberg Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8904-3802","authenticated-orcid":false,"given":"Marie Jose","family":"Kersten","sequence":"additional","affiliation":[{"name":"Department of Hematology Amsterdam University Medical Center  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3101-1194","authenticated-orcid":false,"given":"Sandra","family":"Croockewit","sequence":"additional","affiliation":[{"name":"Department of Hematology Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5011-1820","authenticated-orcid":false,"given":"Sonja","family":"Zweegman","sequence":"additional","affiliation":[{"name":"Department of Hematology Amsterdam University Medical Center  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0771-5231","authenticated-orcid":false,"given":"Lidwine","family":"Tick","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine M\u00e1xima Medical Center  Eindhoven The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0554-8003","authenticated-orcid":false,"given":"Annemiek","family":"Broijl","sequence":"additional","affiliation":[{"name":"Department of Hematology Erasmus MC Cancer Institute University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry","family":"Koene","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Antonius Ziekenhuis  Nieuwegein The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard M. 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