{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:21:25Z","timestamp":1747149685389,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T00:00:00Z","timestamp":1715904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Understanding the impact of induction and maintenance therapy on patients\u2019 quality of life (QoL) is important for treatment selection. This study aims to compare patient\u2010reported QoL between patients treated with KTd or KRd induction therapy and K maintenance therapy or observation. QoL was assessed using the EORTC QOL\u2010C 30 and QOL\u2010MY20 questionnaires in the AGMT\u201002 study, in which 123 patients with newly diagnosed transplant ineligible multiple myeloma were randomized to nine cycles of either KTd or KRd induction therapy, followed by 12 cycles of K maintenance therapy, or observation. Longitudinal assessments showed statistically significant improvements in global health\u2010related QoL, various disease symptoms and pain for both treatment regimens. KTd improved insomnia and fatigue, and KRd improved physical functioning. Cross\u2010sectional comparisons indicated a \u201cslight\u201d superiority of KTd over KRd in several scales, with the exception of higher neuropathy scores with KTd. During maintenance, longitudinal comparisons showed no statistically significant changes. Cross\u2010sectional comparisons revealed a \u201cslight\u201d improvement in cognitive functioning during carfilzomib therapy, but a worsening in most other QoL scales. Induction therapy led to improvements in most QoL items, while maintenance therapy with K maintenance was associated with \u201cslight\u201d or \u201cmoderate\u201d\u00a0impairments in several QoL scales compared with the observation group.<\/jats:p>","DOI":"10.1002\/jha2.925","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T12:39:29Z","timestamp":1715949569000},"page":"494-504","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["QoL during KTd or KRd induction followed by K maintenance or observation in transplant noneligible patients with newly diagnosed multiple myeloma: Longitudinal and cross\u2010sectional analysis of the randomized AGMT 02 study"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3302-8726","authenticated-orcid":false,"given":"Heinz","family":"Ludwig","sequence":"first","affiliation":[{"name":"Wilhelminen Cancer Research Institute c\/o Department of Medicine I, Clinic Ottakring  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Melchardt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Salzburg Cancer Research Institute \u2013 Laboratory for Immunological and Molecular Cancer Research (SCRI\u2010LIMCR), Paracelsus Medical University Cancer Cluster Salzburg  Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilvy","family":"Schweitzer","sequence":"additional","affiliation":[{"name":"Wilhelminen Cancer Research Institute c\/o Department of Medicine I, Clinic Ottakring  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siegfried","family":"Sormann","sequence":"additional","affiliation":[{"name":"Department of Hematology University Clinic for Internal Medicine  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Schreder","sequence":"additional","affiliation":[{"name":"Department of Medicine I Clinic Ottakring  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Andel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II Pyhrn\u2010Eisenwurzen Klinikum Steyr  Steyr Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II LKH Rankweil  Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niklas","family":"Zojer","sequence":"additional","affiliation":[{"name":"Department of Medicine I Clinic Ottakring  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurenz","family":"Sch\u00f6ffmann","sequence":"additional","affiliation":[{"name":"Department for Hematology, Oncology and Palliative Care LKH Hochsteiermark, Standort Leoben  Leoben Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eberhard","family":"Gunsilius","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V Medical University Innsbruck  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Podar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, University Hospital Krems; and Molecular Oncology and Hematology Unit Karl Landsteiner University of Health Sciences, Krems an der Donau  Krems Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0648-4416","authenticated-orcid":false,"given":"Alexander","family":"Egle","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Salzburg Cancer Research Institute \u2013 Laboratory for Immunological and Molecular Cancer Research (SCRI\u2010LIMCR), Paracelsus Medical University Cancer Cluster Salzburg  Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Willenbacher","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V Medical University Innsbruck  Innsbruck Austria"},{"name":"Syndena GmbH Connect to Cure  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewald","family":"W\u00f6ll","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine St. Vinzenz Krankenhaus Zams  Zams Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Ruckser","sequence":"additional","affiliation":[{"name":"Department of Medicine II Clinic Donaustadt  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Bozic","sequence":"additional","affiliation":[{"name":"Department of Medicine II Clinic Donaustadt  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria\u2010Theresa","family":"Krauth","sequence":"additional","affiliation":[{"name":"University Clinic for Internal Medicine I AKH, Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Petzer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I BHS Linz  Linz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clemens","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Clinic for Internal Medicine 3 Kepler University Clinic Linz  Linz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigrid","family":"Machherndl\u2010Spandl","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I Elisabethinen, Linz  Linz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1125-0211","authenticated-orcid":false,"given":"Hermine","family":"Agis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Division of Oncology Medical University Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Fillitz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hanusch Krankenhaus  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song\u2010Yau","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical Clinic and Policlinic I University Clinic Leipzig  Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Knop","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin 5, Schwerpunkt Onkologie\/H\u00e4matologie Klinikum N\u00fcrnberg Nord  N\u00fcrnberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4462-3694","authenticated-orcid":false,"given":"Richard","family":"Greil","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Salzburg Cancer Research Institute \u2013 Laboratory for Immunological and Molecular Cancer Research (SCRI\u2010LIMCR), Paracelsus Medical University Cancer Cluster Salzburg  Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,17]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12590"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021005913"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026458604826"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.03.025"},{"key":"e_1_2_13_6_1","article-title":"Randomized comparison of KRd and KTd induction followed by K maintenance or observation in transplant non\u2010eligible patients with newly diagnosed multiple myeloma (AGMT\u2010MM02 Trial)","author":"Ludwig H","year":"2024","journal-title":"Haematologica"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.5.365"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2007.04.022"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01206.x"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.02776"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2004.10.017"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.02.059"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(60)90061-8"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-011-1224-1"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-12-613927"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/13554794.2019.1666876"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/2050-6511-14-41"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.66.9648"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.662643"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-08325-2"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.185"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1037\/0003-066X.61.4.305"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1037\/0096-3445.134.1.3"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-020-02558-7"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-8-104"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2023.108417"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(22)00693-3"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(22)00738-0"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41687-024-00691-2"}],"container-title":["eJHaem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.925","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T15:41:29Z","timestamp":1724168489000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jha2.925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,17]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/jha2.925"],"URL":"https:\/\/doi.org\/10.1002\/jha2.925","archive":["Portico"],"relation":{},"ISSN":["2688-6146","2688-6146"],"issn-type":[{"type":"print","value":"2688-6146"},{"type":"electronic","value":"2688-6146"}],"subject":[],"published":{"date-parts":[[2024,5,17]]},"assertion":[{"value":"2024-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}