{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T14:09:40Z","timestamp":1772892580107,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T00:00:00Z","timestamp":1718496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Serious infection is common in patients with multiple myeloma due to immune deficiency from the underlying disease and\/or its treatment. Immunoglobulin replacement is one approach to reduce infection risk in these patients. However, few real\u2010world data exist on its use in patients with myeloma. We investigated immunoglobulin use in Australia, New Zealand and Asia\u2010Pacific using registry data and explored its association with survival outcomes. A total of 2374 patients with a median follow\u2010up time of 29.5 months (interquartile range 13.3\u201354.3 months) were included in the analysis \u2013 1673 from Australia, 313 Korea, 281 New Zealand and 107 Singapore. Overall, 7.1% of participants received immunoglobulin replacement within 24 months of diagnosis. Patients who received immunoglobulin replacement were likely to be younger, had lower baseline IgG levels (excluding paraprotein), were more likely to have baseline hypogammaglobulinaemia, baseline severe hypogammaglobulinaemia and abnormal baseline fluorescent in\u2010situ hybridisation status, receive first\u2010line myeloma treatment with immunomodulatory drugs or anti\u2010CD38 therapy and undergo upfront autologous stem cell transplant. In our patient cohort, the use of immunoglobulin was not associated with overall survival benefit at the time of last follow\u2010up (adjusted hazard ratio 0.72, 95% CI 0.46\u20131.14, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.16). Understanding treatment approaches in clinical practice can help support future planning and provision of immunoglobulin resources.<\/jats:p>","DOI":"10.1002\/jha2.938","type":"journal-article","created":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T06:24:40Z","timestamp":1718519080000},"page":"690-697","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Variation in immunoglobulin use and impact on survival in myeloma"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8666-266X","authenticated-orcid":false,"given":"Khai Li","family":"Chai","sequence":"first","affiliation":[{"name":"Transfusion Research Unit School of Public Health and Preventive Medicine Monash University  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cameron","family":"Wellard","sequence":"additional","affiliation":[{"name":"Transfusion Research Unit School of Public Health and Preventive Medicine Monash University  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LTP","family":"Thao","sequence":"additional","affiliation":[{"name":"Transfusion Research Unit School of Public Health and Preventive Medicine Monash University  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Aoki","sequence":"additional","affiliation":[{"name":"Transfusion Research Unit School of Public Health and Preventive Medicine Monash University  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3881-6000","authenticated-orcid":false,"given":"Elizabeth M","family":"Moore","sequence":"additional","affiliation":[{"name":"Transfusion Research Unit School of Public Health and Preventive Medicine Monash University  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley M","family":"Augustson","sequence":"additional","affiliation":[{"name":"Department of Haematology Sir Charles Gairdner Hospital  Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akshay","family":"Bapat","sequence":"additional","affiliation":[{"name":"Department of Haematology Royal Hobart Hospital  Hobart Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilary","family":"Blacklock","sequence":"additional","affiliation":[{"name":"Department of Haematology Middlemore Hospital  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wee J","family":"Chng","sequence":"additional","affiliation":[{"name":"Department of Haematology\u2010Oncology and Cancer Science Institute of Singapore National University Cancer Institute  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Cooke","sequence":"additional","affiliation":[{"name":"Department of Haematology Northern Hospital  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecily J","family":"Forsyth","sequence":"additional","affiliation":[{"name":"Central Coast Haematology North Gosford NSW  Gosford Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeow\u2010Tee","family":"Goh","sequence":"additional","affiliation":[{"name":"Department of Haematology Singapore General Hospital  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7929-1450","authenticated-orcid":false,"given":"Nada","family":"Hamad","sequence":"additional","affiliation":[{"name":"Department of Haematology St Vincent's Hospital Sydney  Sydney Australia"},{"name":"St Vincent's Clinical School University of New South Wales  Sydney Australia"},{"name":"School of Medicine University of Notre Dame  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon J","family":"Harrison","sequence":"additional","affiliation":[{"name":"Department of Haematology Peter MacCallum Cancer Centre and the Royal Melbourne Hospital  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2811-8671","authenticated-orcid":false,"given":"P Joy","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Haematology Royal Prince Alfred Hospital  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay","family":"Hocking","sequence":"additional","affiliation":[{"name":"Department of Haematology Box Hill Hospital  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7445-4660","authenticated-orcid":false,"given":"Ian","family":"Kerridge","sequence":"additional","affiliation":[{"name":"Department of Haematology Royal North Shore Hospital  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8986-8436","authenticated-orcid":false,"given":"Jin Seok","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Haematology Yonsei University College of Medicine Severance Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5878-8895","authenticated-orcid":false,"given":"Kihyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Haematology\u2010Oncology Sungkyunkwan University School of Medicine Samsung Medical Center  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracy","family":"King","sequence":"additional","affiliation":[{"name":"Department of Haematology Royal Prince Alfred Hospital  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4838-9022","authenticated-orcid":false,"given":"Georgia J","family":"McCaughan","sequence":"additional","affiliation":[{"name":"Department of Haematology St Vincent's Hospital Sydney  Sydney Australia"},{"name":"St Vincent's Clinical School University of New South Wales  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Mollee","sequence":"additional","affiliation":[{"name":"Department of Haematology Princess Alexandra Hospital  Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C Orla","family":"Morrissey","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The Alfred Hospital and Monash University  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Haematology Royal Hobart Hospital  Hobart Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Quach","sequence":"additional","affiliation":[{"name":"Department of Haematology St Vincent's Hospital Melbourne  Melbourne Australia"},{"name":"Medicine, Dentistry and Health Sciences The University of Melbourne  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan Ni","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Haematology Sir Charles Gairdner Hospital  Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3943-7229","authenticated-orcid":false,"given":"Allison CY","family":"Tso","sequence":"additional","affiliation":[{"name":"Department of Haematology Tan Tock Seng Hospital  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly 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