{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T02:42:26Z","timestamp":1760409746052,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T00:00:00Z","timestamp":1718582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the current WHO classification, a T\u2010cell prolymphocytic leukemia (T\u2010PLL) diagnosis requires lymphocytosis of &gt;5 \u00d7 109\/L, evidence of monoclonality, and <jats:italic>TCL1A<\/jats:italic> or <jats:italic>MTCP1<\/jats:italic> rearrangement. However, the 2019 consensus document suggested that in the absence of rearrangement of <jats:italic>TCL1<\/jats:italic>\u2010family, the presence of abnormalities involving chromosome 11 (11q22.3; ATM), chromosome 8 (idic(8)(p11), t(8;8), trisomy 8q), 5, 12, 13, 22, or a complex karyotype, as well as involvement specific sites (e.g., splenomegaly, effusions) would suffice for a diagnosis of T\u2010PLL. We present a patient diagnosed with T\u2010PLL with <jats:italic>MTCP1<\/jats:italic> rearrangement who was successfully treated with alemtuzumab followed by consolidative allogeneic unrelated donor stem cell transplantation. Eight years later, the patient presented with inguinal lymphadenopathy with features more akin to peripheral T\u2010cell lymphoma, NOS (PTCL, NOS) of the GATA3 subtype, and there was no evidence of peripheral blood involvement. However, the lymphoma cells were clonally related to those at presentation. Currently, literature on T\u2010PLL\u2010like cases lacking the rearrangement of <jats:italic>TCL1A<\/jats:italic> is limited, and the possibility of whether a proportion of such cases could represent PTCL, NOS (with leukemic involvement) needs consideration.<\/jats:p>","DOI":"10.1002\/jha2.953","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T01:49:58Z","timestamp":1718675398000},"page":"900-904","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Does a subset of mature T\u2010cell leukemias with features akin to T\u2010cell prolymphocytic leukemia but lacking rearrangement of the <i>TCL1<\/i> represent peripheral T\u2010cell lymphoma, NOS in a leukemic phase?"],"prefix":"10.1002","volume":"5","author":[{"given":"David C.","family":"Gajzer","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Division of Hematopathology University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueyan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Division of Hematopathology University of Washington  Seattle Washington USA"},{"name":"Section of Pathology, Translational Science and Therapeutics Division Fred Hutchinson Cancer Center  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5322-0336","authenticated-orcid":false,"given":"Daniel E.","family":"Sabath","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Division of Hematopathology University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Poh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Medical Oncology University of Washington Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3807-3638","authenticated-orcid":false,"given":"Kikkeri N.","family":"Naresh","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Division of Hematopathology University of Washington  Seattle Washington USA"},{"name":"Section of Pathology, Translational Science and Therapeutics Division Fred Hutchinson Cancer Center  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2023.2243354"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2022.01.017"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019003348"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPG71KYOXTKLQW"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqac166"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023020401"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01620-2"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000402"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-023-01956-3"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1309\/02M7-5JCC-YRTK-MGDR"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-010-1026-x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02688-6"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-09-872549"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12856"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241512106"}],"container-title":["eJHaem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.953","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T02:08:09Z","timestamp":1760407689000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jha2.953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,17]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/jha2.953"],"URL":"https:\/\/doi.org\/10.1002\/jha2.953","archive":["Portico"],"relation":{},"ISSN":["2688-6146","2688-6146"],"issn-type":[{"type":"print","value":"2688-6146"},{"type":"electronic","value":"2688-6146"}],"subject":[],"published":{"date-parts":[[2024,6,17]]},"assertion":[{"value":"2024-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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