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In a multicentre, phase II, blinded, randomised, controlled feasibility trial, critically ill patients with platelet count 100\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/L or less were randomised 1:1 to intravenous desmopressin (0.3\u00a0\u00b5g\/kg) or placebo before an invasive procedure. Forty\u2010three participants (18.8% of those eligible) were recruited, with 41 eligible for analysis. Post\u2010procedure bleeding occurred in one of 22 (4.5%) in the placebo arm and zero of 19 in the desmopressin arm. Despite liberal inclusion criteria, there were significant feasibility challenges recruiting patients in the critical care setting prior to invasive procedures.<\/jats:p>","DOI":"10.1002\/jha2.955","type":"journal-article","created":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T06:28:43Z","timestamp":1718519323000},"page":"772-777","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Desmopressin for prevention of bleeding for thrombocytopenic, critically ill patients undergoing invasive procedures: A randomised, double\u2010blind, placebo\u2010controlled feasibility trial"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1951-5616","authenticated-orcid":false,"given":"Michael J. 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