{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T02:42:05Z","timestamp":1760409725643,"version":"build-2065373602"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T00:00:00Z","timestamp":1718582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mixed\u2010phenotype acute leukemia (MPAL) with <jats:italic>FLT3<\/jats:italic>\u2010TKD mutations is a rare and challenging subtype of leukemia. Effective management strategies are crucial for improving patient outcomes. A 31\u2010year\u2010old man with <jats:italic>FLT3<\/jats:italic>\u2010TKD\u2010mutated MPAL achieved hematological remission through the JALSG ALL202\u2010O protocol and gilteritinib, followed by cord blood transplantation (CBT). Post\u2010transplant complications included adenovirus\u2010induced hemorrhagic cystitis, managed with bladder irrigation and ribavirin, and engraftment failure, necessitating a second CBT on Day 35. Subsequent adenoviral conjunctivitis resolved with vidarabine. The patient achieved neutrophil engraftment by Day 76 and was discharged on Day 173 without relapse. This case highlights the importance of vigilant supportive care and tailored therapy in managing MPAL with <jats:italic>FLT3<\/jats:italic> mutations, especially in the context of post\u2010transplant complications.<\/jats:p>","DOI":"10.1002\/jha2.956","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T01:40:08Z","timestamp":1718674808000},"page":"802-809","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Overcoming post\u2010transplant graft failure and adenovirus infection in a patient with <i>FLT3<\/i>\u2010TKD\u2010mutated mixed\u2010phenotype acute leukemia: A case report"],"prefix":"10.1002","volume":"5","author":[{"given":"Yusuke","family":"Takada","sequence":"first","affiliation":[{"name":"Department of Hematology Yokohama Municipal Citizen's Hospital  Yokohama 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