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This case demonstrates the rare diagnosis of AVWS due to an Immunoglobulin G monoclonal gammopathy in an elderly woman who presented with significant gastrointestinal bleeding. Originally thought to be type 1 von Willebrand disease, this case provides a cautious example to clinicians that without a detailed history or an understanding of the associated laboratory work\u2010up, AVWS may be missed with potentially fatal consequences. Fortunately, AVWS was recognized and treated with intravenous immunoglobulin with a resolution of bleeding.<\/jats:p>","DOI":"10.1002\/jha2.969","type":"journal-article","created":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T06:09:17Z","timestamp":1719641357000},"page":"833-837","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intravenous Immunoglobulin offers temporary improvement in acquired von Willebrand syndrome due to monoclonal gammopathy: A case report"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2655-6418","authenticated-orcid":false,"given":"Kevin G.","family":"Zablonski","sequence":"first","affiliation":[{"name":"University Hospitals, Seidman Cancer Center  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aarthi","family":"Rajkumar","sequence":"additional","affiliation":[{"name":"University Hospitals, Seidman Cancer Center  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9534-3502","authenticated-orcid":false,"given":"Lalitha","family":"Nayak","sequence":"additional","affiliation":[{"name":"University Hospitals, Seidman Cancer Center  Cleveland Ohio USA"},{"name":"Department of Internal Medicine Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,29]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"SabihA BabikerHM.von Willebrand disease. 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