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A limited number of cases involving HLH patients with concomitant multiple myeloma (MM), leading to significant mortality, have been documented, underscoring the importance of timely diagnosis. We present the case of a 78\u2010year\u2010old previously healthy male admitted to our hospital with a newly diagnosed MM. Subsequently, he was diagnosed with HLH and received treatment with anakinra, intravenous immunoglobulin, and dexamethasone. This case report highlights the unique aspect of being the first documented instance of myeloma\u2010associated HLH treated with anakinra.<\/jats:p>","DOI":"10.1002\/jha2.975","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T14:37:48Z","timestamp":1720103868000},"page":"1057-1062","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Myeloma\u2010associated hemophagocytic lymphohistiocytosis \u2013 A comprehensive case study and a novel chemotherapy\u2010free approach with anakinra"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5438-3540","authenticated-orcid":false,"given":"Maged","family":"Al\u2010Ammari","sequence":"first","affiliation":[{"name":"Department of Haematology Liverpool Hospital  Liverpool 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