{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:54:53Z","timestamp":1790787293222,"version":"4.1.0"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>High\u2010dose melphalan followed by stem cell rescue is the standard consolidative therapy for transplant\u2010eligible patients with multiple myeloma (MM) in the United Kingdom. A melphalan dose of 200\u00a0mg\/m<jats:sup>2<\/jats:sup> (Mel200) is considered the \u201cgold standard\u201d for autologous stem cell transplant (ASCT) conditioning for fit patients \u226470 years old; however, with a peak diagnosis incidence at 80\u201389 years old in the UK dose adjustments will be inevitable to limit toxicities. In this single\u2010centre UK\u2010based retrospective analysis, data was collected from patients with plasma cell dyscrasias who underwent a first reduced\u2010intensity, Mel140, ASCT from 2006 to 2019, a total of 81 patients. We found that the procedure was overall safe with seven (9%) of patients requiring ITU admission and a single transplant\u2010related death within the initial autograft admission. The progression\u2010free survival (PFS) and overall survival were comparable with those previously reported in the literature with median PFS for our cohort of 31 months. Univariate analysis of our data showed an inferior PFS for patients aged \u226570 years. In conclusion, although this is a retrospective analysis, it demonstrates that dose\u2010reduced melphalan conditioning is safe and effective in patients deemed unfit for standard\u2010intensity conditioning.<\/jats:p>","DOI":"10.1002\/jha2.977","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T13:44:00Z","timestamp":1724075040000},"page":"1102-1106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Outcomes of melphalan 140\u00a0mg\/m<sup>2<\/sup> followed by autologous stem cell transplantation in multiple myeloma patients with co\u2010morbidities: Single\u2010centre experience"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0066-7556","authenticated-orcid":false,"given":"Dario","family":"Melotti","sequence":"first","affiliation":[{"name":"Haematology University College Hospital  London 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