{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:44:43Z","timestamp":1785465883517,"version":"3.56.0"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Treatment of type 3 von Willebrand disease by infusion of von Willebrand factor (VWF) and factor VIII (FVIII) concentrates may lead to the development of anti\u2010VWF antibodies, challenging haemostasis management. The systematic review of the literature presented here retrieved 15 such cases (surgery <jats:italic>n<\/jats:italic>\u00a0=\u00a011, bleeding <jats:italic>n<\/jats:italic>\u00a0=\u00a04). The heterogeneous patient management mostly involved continuous infusion of FVIII, or recombinant FVIIa together with various other strategies. Off\u2010label infusion of the bispecific monoclonal antibody emicizumab was prescribed in three cases and in a complex local case, ultimately well\u2010controlled with emicizumab. This illustrates the fact that emicizumab appears as a therapeutic option in this context of allo\u2010immunisation.<\/jats:p>","DOI":"10.1002\/jha2.984","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T13:45:04Z","timestamp":1721915104000},"page":"964-970","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Bleeding management in type 3 von Willebrand disease with anti\u2010von Willebrand factor inhibitor: A literature review and case report"],"prefix":"10.1002","volume":"5","author":[{"given":"Aur\u00e9lie","family":"Briane","sequence":"first","affiliation":[{"name":"Service de M\u00e9decine Interne Nantes Universit\u00e9, CHU Nantes  Nantes France"},{"name":"Centre de Ressource et de Comp\u00e9tence \u2013 Maladies H\u00e9morragiques Constitutionnelles Nantes Universit\u00e9, CHU Nantes  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2988-5952","authenticated-orcid":false,"given":"Val\u00e9rie","family":"Horvais","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'Investigation Clinique 17 Nantes Universit\u00e9, CHU Nantes  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Sigaud","sequence":"additional","affiliation":[{"name":"Centre de Ressource et de Comp\u00e9tence \u2013 Maladies H\u00e9morragiques Constitutionnelles Nantes Universit\u00e9, CHU Nantes  Nantes France"},{"name":"Service d'H\u00e9matologie Biologique Nantes Universit\u00e9, CHU Nantes  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4072-839X","authenticated-orcid":false,"given":"Marc","family":"Trossa\u00ebrt","sequence":"additional","affiliation":[{"name":"Centre de Ressource et de Comp\u00e9tence \u2013 Maladies H\u00e9morragiques Constitutionnelles Nantes Universit\u00e9, CHU Nantes  Nantes France"},{"name":"Service d'H\u00e9matologie Biologique Nantes Universit\u00e9, CHU Nantes  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6500-5190","authenticated-orcid":false,"given":"Nicolas","family":"Drillaud","sequence":"additional","affiliation":[{"name":"Centre de Ressource et de Comp\u00e9tence \u2013 Maladies H\u00e9morragiques Constitutionnelles Nantes Universit\u00e9, CHU Nantes  Nantes France"},{"name":"Service d'H\u00e9matologie Biologique Nantes Universit\u00e9, CHU Nantes  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Ternisien","sequence":"additional","affiliation":[{"name":"Centre de Ressource et de Comp\u00e9tence \u2013 Maladies H\u00e9morragiques Constitutionnelles Nantes Universit\u00e9, CHU Nantes  Nantes France"},{"name":"Service d'H\u00e9matologie Biologique Nantes Universit\u00e9, CHU Nantes  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0964-0739","authenticated-orcid":false,"given":"Marc","family":"Fouassier","sequence":"additional","affiliation":[{"name":"Centre de Ressource et de Comp\u00e9tence \u2013 Maladies H\u00e9morragiques Constitutionnelles Nantes Universit\u00e9, CHU Nantes  Nantes France"},{"name":"Service d'H\u00e9matologie Biologique Nantes Universit\u00e9, CHU Nantes  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9284-7094","authenticated-orcid":false,"given":"Antoine","family":"Babuty","sequence":"additional","affiliation":[{"name":"Centre de Ressource et de Comp\u00e9tence \u2013 Maladies H\u00e9morragiques Constitutionnelles Nantes Universit\u00e9, CHU Nantes  Nantes France"},{"name":"Service d'H\u00e9matologie Biologique Nantes Universit\u00e9, CHU Nantes  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,25]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1601561"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/beha.2001.0139"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-05-782029"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1987.tb01458.x"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-10-462085"},{"issue":"2","key":"e_1_2_14_7_1","first-page":"117","article-title":"Evidence\u2010based recommendations on the treatment of von Willebrand disease in Italy","volume":"7","author":"Mannucci PM","year":"2009","journal-title":"Blood Transfus"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13165"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000214857"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-017-0793-2"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01668.x"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e3280100d1e"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-16891"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14450"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-01-769018"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02799.x"}],"container-title":["eJHaem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.984","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T10:19:22Z","timestamp":1739355562000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jha2.984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,25]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/jha2.984"],"URL":"https:\/\/doi.org\/10.1002\/jha2.984","archive":["Portico"],"relation":{},"ISSN":["2688-6146","2688-6146"],"issn-type":[{"value":"2688-6146","type":"print"},{"value":"2688-6146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,25]]},"assertion":[{"value":"2024-05-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}