{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T02:09:40Z","timestamp":1761790180943,"version":"build-2065373602"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The efficacy of BCR\u2010ABL tyrosine kinase inhibitors (TKIs) in treating chronic myelogenous leukemia and other malignancies is well\u2010documented. However, concerns about potential nephrotoxicity have raised questions. This study, conducted at Tikur Anbesa Specialized Hospital (TASH) in Addis Ababa, Ethiopia, aimed to investigate the association between TKIs and renal toxicities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A hospital\u2010based cross\u2010sectional design was used to enroll 260 TASH patients actively receiving BCR\u2010ABL TKIs. Demographic information, diagnoses, treatment details, and laboratory test results were collected for each participant's Electronic Medical Record. The primary goal was to assess adverse renal events, a combination of events of a decrease in estimated glomerular filtration rate (eGFR) exceeding 30% from baseline, significant proteinuria, and a diagnosis of acute kidney injury (AKI) or chronic kidney disease (CKD). A logistic regression model was used to analyze the data and identify factors associated with developing adverse renal events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our analysis revealed a statistically significant decrease in eGFR following treatment with TKIs. However, the observed rate of adverse renal events (13.1%) was lower than reported in some previous studies. Factors significantly associated with adverse renal events included longer TKI duration, male sex (protective), hypertension, HIV infection, and achieving complete molecular remission and\/or a complete hematologic response. No significant associations were found with diabetes mellitus, age, angiotensin\u2010converting enzyme inhibitors use, or baseline creatinine level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>While this study found that BCR\u2010ABL TKIs can lead to a decline in eGFR, AKI, and CKD, it also demonstrated that they were relatively safer in our study population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jha2.988","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T11:42:18Z","timestamp":1722426138000},"page":"749-756","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Unveiling the nephrotoxic profile of BCR\u2010ABL tyrosine kinase inhibitors: A real\u2010world experience in Africa"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6025-8619","authenticated-orcid":false,"given":"Zekarias Seifu","family":"Ayalew","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Addis Ababa University  Addis Ababa Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6849-1293","authenticated-orcid":false,"given":"Gebeyehu Tessema","family":"Azibte","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Addis Ababa University  Addis Ababa Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fisihatsion","family":"Tadesse","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology Addis Ababa University  Addis Ababa Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biruk Abate","family":"Legesse","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Addis Ababa University  Addis Ababa Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zerubabel Getahun","family":"Kiflu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Addis Ababa University  Addis Ababa Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahlet Tsige","family":"Weldeamanuel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Addis Ababa University  Addis Ababa Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kibrekidusan Aynekulu","family":"Tsige","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Addis Ababa University  Addis Ababa Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bereket Abraha","family":"Molla","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Addis Ababa University  Addis Ababa Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Addisu Melkie","family":"Ejigu","sequence":"additional","affiliation":[{"name":"Department of Internal 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in estimate glomerular filtration rate associated with long\u2010term tyrosine kinase inhibitor treatment in patients with chronic myelogenous leukemia","volume":"51","author":"Motohashi T","year":"2021","journal-title":"Kitasato Med 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