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We present a case of classic low\u2010grade follicular lymphoma with <jats:italic>IRF4<\/jats:italic> rearrangement in a 50\u2010year\u2010old male, demonstrating an unusual immunophenotypic and genetic profile reminiscent of LBCL\u2010<jats:italic>IRF4<\/jats:italic>\u2010R. Molecular analysis revealed mutations in <jats:italic>CREBBP<\/jats:italic>, <jats:italic>KMT2D<\/jats:italic>, <jats:italic>IRF4<\/jats:italic>, and <jats:italic>CARD11<\/jats:italic>, with previously unreported variants identified in <jats:italic>IRF4<\/jats:italic> and <jats:italic>CREBBP<\/jats:italic>. This case broadens the spectrum of B\u2010cell lymphomas associated with <jats:italic>IRF4<\/jats:italic> rearrangement by demonstrating a small B\u2010cell lymphoma with this genetic feature.<\/jats:p>","DOI":"10.1002\/jha2.992","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T05:13:53Z","timestamp":1724303633000},"page":"1068-1071","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Low\u2010grade follicular lymphoma with interferon regulatory factor\u20104 rearrangement: Expanding the spectrum of interferon regulatory factor\u20104\u2010rearranged lymphomas"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4610-7562","authenticated-orcid":false,"given":"Ali","family":"Sakhdari","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology Laboratory Medicine and Pathobiology University Health Network  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J. 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