{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:18:35Z","timestamp":1788369515113,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T00:00:00Z","timestamp":1371686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2014,2]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Acute cholangitis and cholecystitis (AC<\/jats:styled-content>) often progress to severe septic conditions. We evaluated the endotoxin activity assay (EAA)<\/jats:styled-content> for assessment and prediction of the severity of AC<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>We retrospectively reviewed 98 patients diagnosed with AC<\/jats:styled-content>. We divided them into low (<0.4) and high (\u22650.4) groups based on EAA<\/jats:styled-content> values.<\/jats:p><\/jats:sec>Results<\/jats:title>Endotoxin levels showed no correlation with EAA<\/jats:styled-content> values. Serum C<\/jats:styled-content>\u2010reactive protein (8.57 vs. 5.23\u2009mg\/dl, P<\/jats:styled-content><\/jats:italic> = 0.02), procalcitonin (2.45 vs. 0.48\u2009ng\/ml, P<\/jats:styled-content><\/jats:italic> = 0.004), and the positive culture rate of blood (50% vs. 15%, P<\/jats:styled-content><\/jats:italic> < 0.001) were significantly higher in the high group than in the low group. Platelet counts were significantly lower in the high group than in the low group (23.9 vs. 13.5 104<\/jats:sup>\/ml, P<\/jats:styled-content><\/jats:italic> = 0.004). The ratio of patients with a J<\/jats:styled-content>apanese A<\/jats:styled-content>ssociation for A<\/jats:styled-content>cute M<\/jats:styled-content>edicine disseminated intravascular coagulation score \u22654 (32% vs. 14%, P<\/jats:styled-content><\/jats:italic> = 0.032) was significantly higher in the high group than in the low group. There was a significantly higher percentage of patients with a severe grade of AC<\/jats:styled-content> in the high group than patients with a mild or moderate grade (32% vs. 15%, P<\/jats:styled-content><\/jats:italic> = 0.05).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Endotoxin activity assay is useful for assessment and early prediction of septic conditions due to AC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.10","type":"journal-article","created":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T10:26:36Z","timestamp":1371723996000},"page":"120-127","source":"Crossref","is-referenced-by-count":15,"title":["Severity and prognostic assessment of the endotoxin activity assay in biliary tract infection"],"prefix":"10.1002","volume":"21","author":[{"given":"Mari","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Gastroenterological Surgery Yokohama City University Graduate School of Medicine 3\u20109 Fukuura Kanazawaku Yokohama 239\u20100004 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryusei","family":"Matsuyama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Yokohama City University Graduate School of Medicine 3\u20109 Fukuura Kanazawaku Yokohama 239\u20100004 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Kadokura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Yokohama City University Graduate School of Medicine 3\u20109 Fukuura Kanazawaku Yokohama 239\u20100004 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryutaro","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Yokohama City University Graduate School of Medicine 3\u20109 Fukuura Kanazawaku Yokohama 239\u20100004 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