{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:22:26Z","timestamp":1791638546995,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T00:00:00Z","timestamp":1626998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["CMRPG3I0103"],"award-info":[{"award-number":["CMRPG3I0103"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The incidence of biliary events (BE) following percutaneous cholecystostomy (PC) in acute cholecystitis (AC) patients is high. Therefore, definitive laparoscopic cholecystectomy (LC) is recommended. We aimed to investigate the optimal timing of LC following PC with regard to the clinical course and pathological findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All 744 AC patients with PC were included. The incidence and median number of BE were investigated with the concept of competing risks. The 344 patients with interval LC were divided into two groups based on the pathological findings of resected gallbladders: the acute\/acute\u2010and\u2010chronic group (AANC group) (n\u00a0=\u00a0221) and the chronic group (n\u00a0=\u00a0123). A comparative analysis of the demographic data and perioperative outcomes was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 744 AC patients with PC, 142 patients experienced recurrent BE. The cumulative incidence of BE was 26.6%, and the median time to recurrence was 67.5\u00a0days. The PC\u2010to\u2010LC days of the chronic group were longer than those of the AANC group (73.51 vs 63.00, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). The multivariate analysis indicated that the operation time was longer in the AANC group than in the chronic group (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.040).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In terms of the clinical course and sequential pathological changes in the gallbladder, a 9\u2010 to 10\u2010week interval after PC is the optimal timing for LC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.1012","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T18:21:34Z","timestamp":1623781294000},"page":"751-759","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The optimal timing of interval laparoscopic cholecystectomy following percutaneous cholecystostomy based on pathological findings and the incidence of biliary events"],"prefix":"10.1002","volume":"28","author":[{"given":"Yu\u2010Liang","family":"Hung","sequence":"first","affiliation":[{"name":"Division of General Surgery Chang Gung Memorial Hospital Taoyuan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan\u2010Wu","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Emergency and Critical Care Radiology Department of Medical Imaging and Intervention Chang Gung Memorial Hospital Taoyuan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Yi","family":"Tsai","sequence":"additional","affiliation":[{"name":"Division of General Surgery Chang Gung Memorial Hospital Taoyuan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tse\u2010Ching","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology College of Medicine Linkou Chang Gung Memorial Hospital Chang Gung University Taoyuan City 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