{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T16:40:13Z","timestamp":1757608813067,"version":"3.44.0"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T00:00:00Z","timestamp":1628294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Purpose<\/jats:title><jats:p>There is no evidence regarding the optimal balloon dilation time during endoscopic papillary large balloon dilation (EPLBD). The study aim was to evaluate the efficacy of 2\u2010minute extended balloon dilation for EPLBD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred and five patients who underwent EPLBD during endoscopic retrograde cholangiopancreatography (ERCP) for bile duct stones at three tertiary centers were included in the analysis. Clinical outcomes and the adverse events were compared between the 0\u2010minute group (n\u00a0=\u00a094, balloon deflated immediately after waist disappearance) and the 2\u2010minute group (n\u00a0=\u00a0111, balloon dilation maintained for 2\u00a0minutes after waist disappearance). The risk factors of post\u2010ERCP pancreatitis (PEP) after EPLBD were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences in the stone removal rates and hospitalization periods between the two groups. However, the total ERCP procedure time was significantly shorter in the 2\u2010minute group (40.6 vs 48.9\u00a0min, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03). The incidence of PEP was 7.4% in the 0\u2010minute group and significantly lower at 0.9% in the 2\u2010minute group (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.04). Multivariate analysis identified without 2\u2010minute extended EPLBD as a significant risk factor of PEP (OR: 9.9, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.045).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Extension of EPLBD for 2 minutes helped prevent PEP and shortened the procedure time.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.1029","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T14:52:34Z","timestamp":1627656754000},"page":"932-940","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy of endoscopic large balloon dilation extended for 2\u00a0minutes in bile duct stone removal: A multicenter retrospective study"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0915-030X","authenticated-orcid":false,"given":"Kazunari","family":"Nakahara","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology School of Medicine St. Marianna University  Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Michikawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology School of Medicine St. Marianna University  Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keigo","family":"Suetani","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kawasaki Municipal Tama Hospital  Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0514-4452","authenticated-orcid":false,"given":"Junya","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology School of Medicine St. Marianna University  Kawasaki 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