{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:21:42Z","timestamp":1747149702784,"version":"3.40.5"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T00:00:00Z","timestamp":1633651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Invasive gallbladder carcinoma generally presents as nodular\u2010sclerosing growth. Recently, \u201cpolypoid invasive carcinoma (PICA)\u201d showing grossly visible polypoid neoplasm and histologically invasive carcinoma with no adenomatous components was proposed as a neoplastic polyp of the gallbladder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We herein report five cases of PICA collected from 49 cases of invasive gallbladder carcinoma in comparison with another polypoid preinvasive neoplasm of gallbladder, intracholecystic papillary neoplasm (ICPN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Polypoid invasive carcinomas were composed of four males and one female with an average age of 74\u00a0years. Polypoid lesions were sessile (height ranging from 6 to 10\u00a0mm and the largest diameter ranging from 12 to 40\u00a0mm), and histologically, polypoid neoplasms presented papillary configuration containing tubular and cribriform components with thin inflammatory, fibrotic stroma. Polypoid carcinoma invaded directly and continuously into the gallbladder wall with destruction of the muscle layer. These patterns of PICA were different from ICPN, showing papillary patterns containing tubular components with fine fibrovascular stalks and with occasional focal stromal invasion but with preserved muscle layer. Post\u2010operative outcome was not favorable in PICA but was favorable in ICPN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Polypoid invasive carcinoma shared several pathological features with ICPN, such as intraluminal polypoid pattern with papillary configurations, but PICAs were invasive adenocarcinoma with destruction of muscle layer while ICPNs were preinvasive neoplasm with occasional focal stromal invasion, thus both should be differentiated from each other.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.1051","type":"journal-article","created":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T19:00:51Z","timestamp":1632942051000},"page":"531-539","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Polypoid invasive carcinoma of the gallbladder\u2010Another challenging polypoid neoplasm\u2010"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4117-6611","authenticated-orcid":false,"given":"Yasuni","family":"Nakanuma","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology Shizuoka Cancer Center  Sunto\u2010gun Japan"},{"name":"Department of Diagnostic Pathology Fukui Prefecture institute  Fukui Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Sugino","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Shizuoka Cancer Center  Sunto\u2010gun Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshikatsu","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Digestive Medicine Fukui\u2010ken Saiseikai Hospital  Fukui Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Digestive Medicine Fukui\u2010ken Saiseikai Hospital  Fukui Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuro","family":"Terada","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgery Fukui Prefecture Saiseikai Hospital  Fukui Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,8]]},"reference":[{"volume-title":"WHO Classification of Tumours","year":"2019","author":"WHO Classification of Tumours Editorial Board","key":"e_1_2_6_2_1"},{"volume-title":"WHO Classification of Tumours","year":"2010","author":"Bosman FT","key":"e_1_2_6_3_1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2021.06.007"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2021.151723"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-020-02877-7"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001117"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0237979"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/hpb.12444"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.55418\/9781933477343"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318262787c"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000131"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001237"},{"issue":"8","key":"e_1_2_6_14_1","first-page":"S1365","article-title":"A clinicopathological reappraisal of intraductal papillary neoplasm of the bile duct (IPNB): a continuous spectrum with papillary cholangiocarcinoma in 181 curatively resected cases","volume":"23","author":"Onoe S","year":"2021","journal-title":"HPB (Oxford)"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.5858\/2005-129-905-PCOTGA"},{"key":"e_1_2_6_16_1","first-page":"1","volume-title":"Pathology of the Pancreas, Gallbladder, Extrahepatic Biliary Tract, and Ampullary Region","author":"Lack EE","year":"2003"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2021.05.001"}],"container-title":["Journal of Hepato-Biliary-Pancreatic Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jhbp.1051","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jhbp.1051","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jhbp.1051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T10:24:37Z","timestamp":1692872677000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jhbp.1051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,8]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1002\/jhbp.1051"],"URL":"https:\/\/doi.org\/10.1002\/jhbp.1051","archive":["Portico"],"relation":{},"ISSN":["1868-6974","1868-6982"],"issn-type":[{"type":"print","value":"1868-6974"},{"type":"electronic","value":"1868-6982"}],"subject":[],"published":{"date-parts":[[2021,10,8]]},"assertion":[{"value":"2021-07-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}