{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:46:01Z","timestamp":1786977961011,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T00:00:00Z","timestamp":1634688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The duration of perioperative antibiotic prophylaxis following live liver donor hepatectomy (LDH) is not known.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a double\u2010blind equivalence trial. All consecutive LDH were randomized into: group A (three doses) and group B (nine doses) of perioperative antibiotics (piperacillin\u00a0+\u00a0tazobactam\u00a0\u2212\u00a04.5\u00a0g intravenous) at fixed 8\u00a0hourly intervals. Primary end point was incidence of infective complications as per CDC (Centers for Disease Control and Prevention) criteria. Secondary end points were liver function tests, total leukocyte count, international normalized ratio, hospital stay, morbidity, and cost analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One hundred and twenty\u2010six LDHs were enrolled. A total of 19.8% (n\u00a0=\u00a025) experienced postoperative complications, 11 (17.7%) in group A and 14 (21.9%) in group B (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.561). Infective complications were seen in 11 donors (8.1%), five in group A and six in group B (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.79). A total of 8.1% of donors required continuation\/up\u2010gradation of antibiotics in group A and 9.4% in group B. Return to soft diet was delayed in group B (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.039). Median hospital stay and cost were similar.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Three doses of perioperative antibiotic are equally effective in preventing infective complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jhbp.1053","type":"journal-article","created":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T05:13:13Z","timestamp":1633756393000},"page":"1124-1132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Randomized control trial on perioperative antibiotic prophylaxis in live liver donors: Are three doses enough?"],"prefix":"10.1002","volume":"29","author":[{"given":"Sahil","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Hepato\u2010Pancreato\u2010Biliary and Liver Transplant Surgery Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piyush Kumar","family":"Sinha","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Pancreato\u2010Biliary and Liver Transplant Surgery Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilesh Sadashiv","family":"Patil","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Pancreato\u2010Biliary and Liver Transplant Surgery Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihar","family":"Mohapatra","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Pancreato\u2010Biliary and Liver Transplant Surgery Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Sindwani","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Critical Care Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Critical Care Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Khillan","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2597-8625","authenticated-orcid":false,"given":"Viniyendra","family":"Pamecha","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Pancreato\u2010Biliary and Liver Transplant Surgery Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072\u2010016\u20109715\u20108"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24374"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.04.018"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25445"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm028"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2017.0904"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006933.pub2"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2012.08.016"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102168.1998.00606.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620\u2010015\u20104008\u2010y"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002049"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ags3.12267"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072\u2010017\u20109832\u2010z"},{"key":"e_1_2_8_15_1","unstructured":"CDC\/NHSN Surveillance Definitions for Specific Types of Infections.Centers for Disease Control and Prevention website. 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