{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T23:15:49Z","timestamp":1768691749422,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T00:00:00Z","timestamp":1637107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Approximately 8300 hemophiliacs are registered in Japan, but no comprehensive reports on hepatobiliary and pancreatic surgery (HBPS) have been conducted. This report investigates the current status of HPBS in hemophilia patients in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The subjects were hemophiliac patients seen between January 1 2007, and December 31 2017, at facilities participating in this study among the facilities for performing high\u2010difficulty cases nationwide designated by the Japanese Society for HBPS. A retrospective examination of short\u2010term outcomes in 49 cases was conducted to assess patient background, disease, surgical procedure, and complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The types of hemophilia were A: 43 cases, B: four cases, and von Willebrand disease: two cases (hemophilia severity: mild 32, moderate seven, severe 10). The target malignant diseases for surgery were hepatocellular carcinoma (HCC) in 20 cases, intrahepatic cholangiocellular carcinoma (CCC) in four cases, combined HCC\u2010CCC in two cases, hilar CCC in two cases, and pancreatic cancer in four cases. As for the surgical procedure, limited resection (subsegmentectomy and partial hepatectomy) was performed in 16 cases of HCC even with normal liver function tests. Pancreaticoduodenectomy and distal pacreatectomy were performed for pancreatic cancers as in the standard procedure. Postoperative complications were postoperative bleeding in two cases after hepatectomy and one after pancreatectomy in one case. When compared with Japanese National Clinical Data base, the complication rates after hepatectomy and pancreatectomy were not conspicuous in hemophilic patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>As long as they are performed in qualified centers, complication rate is not increased in hemophilic patients undergoing HBPS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.1073","type":"journal-article","created":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T21:02:57Z","timestamp":1635886977000},"page":"385-393","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["National survey of hepatobiliary and pancreatic surgery in hemophilia patients in Japan"],"prefix":"10.1002","volume":"29","author":[{"given":"Tomoko","family":"Yoshimoto\u2010Haramura","sequence":"first","affiliation":[{"name":"Department of Surgery Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8191-6405","authenticated-orcid":false,"given":"Masaaki","family":"Hidaka","sequence":"additional","affiliation":[{"name":"Department of Surgery Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8734-740X","authenticated-orcid":false,"given":"Kiyoshi","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Hepato\u2010Biliary\u2010Pancreatic Surgery Division Artificial Organ and Transplantation Division Department of Surgery Graduate School of Medicine The University of Tokyo  Bunkyo\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Suzumura","sequence":"additional","affiliation":[{"name":"Department of Surgery Hyogo College of Medicine  Nishinomiya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Takemura","sequence":"additional","affiliation":[{"name":"Department of Surgery National Center for Global Health and Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Hama","sequence":"additional","affiliation":[{"name":"Department of Surgery National Hospital Organization Osaka National Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology Department of Surgery Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeo","family":"Nomi","sequence":"additional","affiliation":[{"name":"Department of Surgery Nara Medical University  Kashihara\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7364-1798","authenticated-orcid":false,"given":"Tsuyoshi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Transplant Surgery Graduate School of Biomedical and Health Sciences Hiroshima University  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Sano","sequence":"additional","affiliation":[{"name":"Department of Surgery Teikyo University School of Medicine  Itabashi\u2010Ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Yokomizo","sequence":"additional","affiliation":[{"name":"Department of Surgery Japanese Red Cross Kumamoto Hospital  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1606-4773","authenticated-orcid":false,"given":"Hiroyuki","family":"Nitta","sequence":"additional","affiliation":[{"name":"Department of Surgery Iwate Medical University  Morioka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanao","family":"Kurata","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Hepato\u2010Biliary\u2010Pancreatic Surgery Faculty of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4990-0419","authenticated-orcid":false,"given":"Yasushi","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Surgery Keio University School of Medicine  Shinjuku\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Nagayama","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology and Gastroenterological Surgery Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaji","family":"Tani","sequence":"additional","affiliation":[{"name":"Department of Surgery Shiga University of Medical Science Seta Tsukiniwa\u2010Cho  Otsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takumi","family":"Fukumoto","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic Surgery Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Ohta","sequence":"additional","affiliation":[{"name":"Departments of Gastroenterological and Pediatric Surgery Oita University Faculty of Medicine  Yufu 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