{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T14:13:58Z","timestamp":1781014438867,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T00:00:00Z","timestamp":1643068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770622"],"award-info":[{"award-number":["81770622"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971310"],"award-info":[{"award-number":["81971310"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hepatitis B virus\u2010related acute\u2010on\u2010chronic liver failure (HBV\u2010ACLF) is a life\u2010threatening disease with high short\u2010term mortality. Early and accurate prognosis is significant for clinical decisions, in which liver volume (LV) imparts important information. However, LV has not been considered in current prognostic models for HBV\u2010ACLF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three hundred and twenty\u2010three patients were recruited to the deriving cohort, while 163 were enrolled to validation cohort. The primary end\u2010point was death within 28\u00a0days since admission. Estimated liver volume (ELV) was calculated by the formula based on healthy population. Logistic regression was used to develop a prediction model. Accuracy of models were evaluated by receiver operating characteristic (ROC) curves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ratio of LV to ELV (LV\/ELV%) was significantly lower in non\u2010survivors, and LV\/ELV% \u226482% indicated poor prognosis. <jats:styled-content><jats:bold>L<\/jats:bold><\/jats:styled-content>V\/<jats:styled-content><jats:bold>E<\/jats:bold><\/jats:styled-content>LV%, <jats:bold><jats:styled-content>A<\/jats:styled-content><\/jats:bold>ge, prothrombin time (<jats:styled-content><jats:bold>P<\/jats:bold><\/jats:styled-content>T), the grade of hepatic encephalopathy (<jats:styled-content><jats:bold>H<\/jats:bold><\/jats:styled-content>E), ln\u2010transformed total bilirubin (lnT<jats:styled-content><jats:bold>B<\/jats:bold><\/jats:styled-content>il), and log\u2010transformed HBV DNA (Log<jats:sub>10<\/jats:sub> HB<jats:styled-content><jats:bold>V<\/jats:bold><\/jats:styled-content> DNA) were identified as independent predictors to develop an LV\u2010based model, LEAP\u2010HBV. The mean area under the ROC (AUC) of LEAP\u2010HBV was 0.906 (95% CI, 0.904\u20100.908), higher than other non\u2010LV\u2010based models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Liver volume was an independent predictor, and LEAP\u2010HBV, a prediction model based on LV, was developed for the short\u2010term mortality in HBV\u2010ACLF.<\/jats:p><jats:p>This study was registered on ClinicalTrails (NCT03977857).<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.1112","type":"journal-article","created":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T07:43:02Z","timestamp":1642146182000},"page":"1253-1263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Liver volume based prediction model for patients with hepatitis B virus\u2010related acute\u2010on\u2010chronic liver failure"],"prefix":"10.1002","volume":"29","author":[{"given":"Chunhua","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases First Affiliated Teaching Hospital School of Medicine (SOM) Xi'an Jiaotong University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Xi'an Eighth Hospital School of Medicine (SOM) Xi'an Jiaotong University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zheng","sequence":"additional","affiliation":[{"name":"Clinical Research Centre First Affiliated Teaching Hospital School of Medicine (SOM) Xi'an Jiaotong University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology First Affiliated Teaching Hospital School of Medicine (SOM) Xi'an Jiaotong University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Ankang Central Hospital  Ankang District Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases First Affiliated Teaching Hospital School of Medicine (SOM) Xi'an Jiaotong University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Weinan Central Hospital  Weinan District Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijie","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases First Affiliated Teaching Hospital School of Medicine (SOM) Xi'an Jiaotong University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases First Affiliated Teaching Hospital School of Medicine (SOM) Xi'an Jiaotong University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine  Xianyang District Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases First Affiliated Teaching Hospital School of Medicine (SOM) Xi'an Jiaotong University  Xi'an Shaanxi 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