{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T16:53:03Z","timestamp":1781628783801,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T00:00:00Z","timestamp":1644278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A history of familial pancreatic cancer (FPC) increases the incidence of pancreatic cancer (PC) among first\u2010degree relatives. We aimed to determine the incidence of FPC and analyze its clinical characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between 2010 and 2014, 1159 patients with PC were included in the study. We evaluated the incidence of FPC, clinicopathological features, and survival prognosis between FPC and non\u2010FPC patients. We further analyzed the clinical outcomes of 389 patients with PC who underwent curative\u2010intent surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Familial pancreatic cancer incidence was 3.1% (n\u00a0=\u00a036) among all patients with PC (n\u00a0=\u00a01159). FPC was diagnosed at an advanced clinical stage compared to non\u2010FPC (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.041). The tested variables and 5\u2010year survival rate (5YSR) between FPC and non\u2010FPC after propensity score matching had no differences (5YSR: 4.6% vs 2.6%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.834). Among PC patients who underwent curative\u2010intent surgery (n\u00a0=\u00a0389), FPC incidence was 1.8% (n\u00a0=\u00a07). FPC patients were older than non\u2010FPC patients (75.3\u00a0\u00b1\u00a04.7\u00a0years vs 64.0\u00a0\u00b1\u00a09.9\u00a0years, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). 5YSR tended to differ between FPC and non\u2010FPC (14.3% vs 22.5%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.07) groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Familial pancreatic cancer is diagnosed at an advanced stage, and FPC that has undergone resection is associated with older age or worse prognosis. A prospective nationwide pedigree registration system was required.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.1117","type":"journal-article","created":{"date-parts":[[2022,1,22]],"date-time":"2022-01-22T02:29:12Z","timestamp":1642818552000},"page":"659-669","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The incidence and clinical features of familial pancreatic cancer in Korea"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1230-4055","authenticated-orcid":false,"given":"Minseob","family":"Kim","sequence":"first","affiliation":[{"name":"Departments of Surgery and Cancer Research Institute Seoul National University College of Medicine  Seoul South 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