{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T06:14:31Z","timestamp":1784268871210,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:00:00Z","timestamp":1646179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recent studies have suggested the suboptimal efficacy of liposomal irinotecan plus 5\u2010fluorouracil\/leucovorin (nal\u2010IRI+5\u2010FU\/LV) in metastatic pancreatic ductal adenocarcinoma (mPDAC) patients previously treated with conventional irinotecan. This study investigated the effect of conventional irinotecan treatment in mPDAC patients receiving nal\u2010IRI+5\u2010FU\/LV by analyzing a population\u2010based dataset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed 667 consecutive mPDAC patients treated with nal\u2010IRI+5\u2010FU\/LV between August 2018 and November 2020 at Taiwanese medical centers. Eighty\u2010six patients previously treated with conventional irinotecan were matched to 86 patients not treated with conventional irinotecan, following propensity matching for age, sex, performance status, metastatic organ site, pre\u2010treatment carbohydrate antigen 19\u20109 level, lines of prior chemotherapy treatment, and time from first\u2010line treatment to nal\u2010IRI+5\u2010FU\/LV therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median overall survival and time\u2010to\u2010treatment failure were 4.8 and 2.6 vs 4.1 and 2.1\u00a0months, respectively, for patients who were and were not previously treated with conventional irinotecan. The tumor response and disease control rates were 5.8% and 32.6% vs 5.8% and 37.2%, respectively, for patients previously treated and not treated with conventional irinotecan. No significant differences were observed in survival times and tumor response rates between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Previous conventional irinotecan treatment does not compromise the efficacy of subsequent nal\u2010IRI+5\u2010FU\/LV treatment in mPDAC patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.1128","type":"journal-article","created":{"date-parts":[[2022,2,19]],"date-time":"2022-02-19T09:59:09Z","timestamp":1645264749000},"page":"670-681","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of previous conventional irinotecan treatment in patients with pancreatic cancer being treated with liposomal irinotecan plus 5\u2010fluorouracil and leucovorin"],"prefix":"10.1002","volume":"29","author":[{"given":"Tai\u2010Jan","family":"Chiu","sequence":"first","affiliation":[{"name":"Division of Hematology\u2010Oncology Department of Internal Medicine Chang Gung Memorial Hospital and Chang Gung University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2010Hung","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Oncology National Taiwan University Hospital and National Taiwan Univeristy  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sz\u2010Chi","family":"Chiu","sequence":"additional","affiliation":[{"name":"PharmaEngine, Inc.  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun\u2010Wen","family":"Hsueh","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology Department of Internal Medicine Keelung Chang Gung Memorial Hospital and Chang Gung University  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nai\u2010Jung","family":"Chiang","sequence":"additional","affiliation":[{"name":"National Institute of Cancer Research National Health Research Institutes  Tainan Taiwan"},{"name":"Division of Hematology and Oncology Department of Internal Medicine National Cheng Kung University Hospital College of Medicine National Cheng Kung University  Tainan Taiwan"},{"name":"School of Medicine College of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung\u2010Pin","family":"Li","sequence":"additional","affiliation":[{"name":"School of Medicine College of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Division of Clinical Skills Training Department of Medical Education Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Division of Gastroenterology and Hepatology Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Yuan","family":"Bai","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology Department of Internal Medicine China Medical University Hospital and China Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu\u2010Ming","family":"Cheng","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology Department of Internal Medicine China Medical University Hospital and China Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2010Chang","family":"Chuang","sequence":"additional","affiliation":[{"name":"Division of General and Digestive Surgery Department of Surgery Kaohsiung Medical University Hospital and Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2457-5189","authenticated-orcid":false,"given":"Yan\u2010Shen","family":"Shan","sequence":"additional","affiliation":[{"name":"Division of General Surgery Department of Surgery National Cheng Kung University Hospital Institute of Clinical Medicine College of Medicine National Cheng Kung University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De\u2010Chuan","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of General Surgery Department of Surgery Tri\u2010Service General Hospital National Defense Medical Center  Taipei 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Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0361-4548","authenticated-orcid":false,"given":"Wen\u2010Chi","family":"Chou","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology Department of Internal Medicine Linkou Chang Gung Memorial Hospital and College of Medicine Chang Gung University  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_10_3_1","unstructured":"Cancer registry annual report. 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