{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T22:48:53Z","timestamp":1782168533762,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bilateral hepatolithiasis is an intractable disease and repeated attacks of acute cholangitis seriously threaten patient health. The surgical approaches evolve along with gradually greater understanding of its pathophysiology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective cohort study for bilateral hepatolithiasis from January 1958 to December 2018. Before May 1993 (Group A, n\u00a0=\u00a070), three surgical approaches were adopted: 37 patients with common bile duct exploration (CBDE), 29 with choledochoenterostomy (CE) and four with partial hepatectomy (PH). After June 1993 (Group B, n\u00a0=\u00a0150), 101 patients underwent Oddi sphincter\u2010preserved cholangioplasty with hepatico\u2010subcutaneous stoma (OSPCHS), and 16 with CBDE, 21 with CE, 12 with PH. The perioperative and long\u2010term outcomes were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 1993, the cholangitis recurrence rate significantly decreased from 49.2% to 20.9%, and the stone recurrence rate from 76.3% to 37.1% (both <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Also, the stone\u2010\/cholangitis\u2010free durations were prolonged significantly (median: 50.8 vs 26.4\/49.6 vs 16.2\u2009months, both <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Preoperative cholangitis was an independent risk factor for stone recurrence (hazard ratio [HR]\u00a0=\u00a01.863, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.018), and residual stone for cholangitis recurrence (HR\u00a0=\u00a02.838, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). OSPCHS and PH were protective surgical approaches for recurrent stone (CBDE: reference; OSPCHS: HR\u00a0=\u00a0.469, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.016, PH: HR\u00a0=\u00a0.219, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.018) and cholangitis (CBDE: reference; OSPCHS: HR\u00a0=\u00a0.421, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.010, PH: HR\u00a0=\u00a0.283, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.093).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>For bilateral hepatolithiasis, the management should focus on hepatobiliary lesion eradication and Oddi sphincter function preservation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.1204","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T04:49:27Z","timestamp":1657169367000},"page":"994-1003","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Long\u2010term outcomes of surgical approaches for bilateral hepatolithiasis: A real\u2010world six\u2010decade experience at a single center"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6057-0123","authenticated-orcid":false,"given":"Jie","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of General Surgery Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of General Surgery Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunsheng","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of General Surgery Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of General Surgery Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingfu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2647-4020","authenticated-orcid":false,"given":"Xiaofeng","family":"Ling","sequence":"additional","affiliation":[{"name":"Department of General Surgery Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianrong","family":"Xiu","sequence":"additional","affiliation":[{"name":"Department of General Surgery Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.116"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2009.04.009"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-014-3669-5"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.140.10.993"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1477-2574.2009.00046.x"},{"key":"e_1_2_6_7_1","first-page":"137","article-title":"Long\u2010term outcomes of choledochoduodenostomy for hepatolithiasis","volume":"123","author":"Ling XF","year":"2010","journal-title":"Chin Med 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