{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:02:49Z","timestamp":1790787769414,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T00:00:00Z","timestamp":1721260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Endoscopic variceal ligation and sclerotherapy are recommended for esophagogastric variceal bleeding (EGVB) in cirrhosis but can be complicated by early rebleeding and death. This study aimed to identify noninvasive markers accurately predicting early rebleeding and mortality after endoscopic hemostasis for EGVB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Among 116 patients with endoscopically confirmed EGVB and endoscopic hemostasis, various noninvasive markers were calculated, and their predictive accuracy was compared by receiver\u2010operating characteristic curve analysis. Endpoints included 5\u2010day rebleeding, 5\u2010day mortality, 6\u2010week rebleeding, and 6\u2010week mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age was 63\u2009years. Child\u2010Pugh class B and C patients accounted for 40.5% and 34.5%, respectively. Only the aspartate aminotransferase\u2010to\u2010platelet ratio index (APRI) significantly predicted 5\u2010day rebleeding, with an area under the curve (AUC) of 0.777 (95% confidence interval\u2009[CI]: 0.537\u20131). The model for end\u2010stage liver disease\u2010Na (MELD\u2010Na) score showed good predictive accuracy for 5\u2010day mortality (AUC: 0.839, 95% CI: 0.681\u20130.997), 6\u2010week rebleeding (AUC: 0.797, 95% CI: 0.663\u20130.932), and 6\u2010week mortality (AUC: 0.888, 95% CI: 0.797\u20130.979).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with cirrhosis with a high APRI and MELD\u2010Na score were at high risk of early rebleeding and death after EGVB. Allocating appropriate monitoring and care for those patients is necessary.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.12057","type":"journal-article","created":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T09:10:33Z","timestamp":1721293833000},"page":"830-839","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Predicting early rebleeding and mortality after endoscopic hemostasis of esophagogastric varices: Diagnostic performance of aspartate aminotransferase\u2010to\u2010platelet ratio index and model for end\u2010stage liver disease\u2010Na score"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7814-8828","authenticated-orcid":false,"given":"Shinya","family":"Yokoyama","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Nagoya Aichi 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