{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T20:00:58Z","timestamp":1783886458373,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100016342","name":"Ministry of Health Mexico","doi-asserted-by":"publisher","award":["JPMH23FC1026"],"award-info":[{"award-number":["JPMH23FC1026"]}],"id":[{"id":"10.13039\/100016342","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to evaluate the outcomes and complications of secondary hepatolithiasis following choledochoenterostomy to guide suitable management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study analyzed 127 patients from a 2017 national survey conducted by the Ministry of Health, Labor, and Welfare. The 2023 cohort study assessed residual stones, recurrences, cholangitis, cholangiocarcinoma, and prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow\u2010up duration was 48\u2009months. Balloon endoscopy\u2010assisted endoscopic retrograde cholangiography (BE\u2010ERC) was the most common treatment, achieving complete stone clearance in 84.4% of patients. Anatomical hepatectomy was the most common surgery. Predictors of residual stones were stone number \u226510 (odds ratio [OR], 7.480; <jats:italic>p<\/jats:italic>\u2009=\u2009.028) and stone diameter \u226510\u2009mm (OR, 5.280; <jats:italic>p<\/jats:italic>\u2009=\u2009.020). Predictors of stone recurrence during follow\u2010up were biliary strictures (hazard ratio [HR], 3.580; <jats:italic>p<\/jats:italic>\u2009=\u2009.005) and cholangitis (HR, 2.700; <jats:italic>p<\/jats:italic>\u2009=\u2009.037). Predictors of cholangitis during follow\u2010up were biliary stricture (HR, 5.016; <jats:italic>p<\/jats:italic>\u2009=\u2009.006) and dilatation (HR, 3.560; <jats:italic>p<\/jats:italic>\u2009=\u2009.029). Any treatment for hepatolithiasis reduced cholangitis occurrence (HR, 0.168; <jats:italic>p<\/jats:italic>\u2009=\u2009.042). Balloon dilation combined with stenting for \u22653\u2009months improved biliary strictures in 57.1% of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study recommends BE\u2010ERC as the first\u2010choice treatment for secondary hepatolithiasis. Stone removal and relief of biliary strictures and dilatation are crucial to prevent stone recurrence and cholangitis after treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.12061","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T06:56:40Z","timestamp":1721804200000},"page":"716-725","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Assessing outcomes and complications of secondary hepatolithiasis after choledochoenterostomy: A nationwide survey in Japan"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2603-5688","authenticated-orcid":false,"given":"Yutaka","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Gastroenterological Surgery Kyorin University Suginami Hospital  Tokyo 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