{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:41:21Z","timestamp":1783442481812,"version":"3.54.6"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T00:00:00Z","timestamp":1724630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Serum amylase (AMY) levels measured 2\u20136\u2009h after ERCP are a predictor of post\u2010ERCP pancreatitis (PEP). Trypsin is one of the pancreatic enzymes elevated in the development of PEP. The study assessed whether serum trypsin (TRY) can predict early\u2010stage PEP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective study included patients who underwent ERCP from June 2022 to May 2023. TRY, AMY, serum pancreatic AMY (P\u2010AMY), and serum lipase (LIP) levels were measured immediately after ERCP and 2\u2009h later. The primary outcome was the diagnostic abilities of TRY levels measured immediately (0\u2009h\u2010TRY) and 2\u2009h after (2\u2009h\u2010TRY) ERCP to predict PEP (compared with the other serum pancreatic enzymes).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 130 patients analyzed, 18 developed PEP. The sensitivity and specificity of 0\u2009h\u2010TRY were 83.3% and 69.6%, respectively, and those of 2\u2009h\u2010TRY were 88.9% and 72.3%, respectively. The area under the curve (AUC) for 0\u2009h\u2010TRY was significantly higher than that for 0\u2009h\u2010AMY (<jats:italic>p<\/jats:italic>\u2009=\u2009.006) and 0\u2009h\u2010P\u2010AMY (<jats:italic>p<\/jats:italic>\u2009=\u2009.012), whereas the AUCs for 0\u2009h\u2010TRY and 0\u2009h\u2010LIP did not differ significantly (<jats:italic>p<\/jats:italic>\u2009=\u2009.563). The AUC for 2\u2009h\u2010TRY for predicting PEP was significantly higher than that for 2\u2009h\u2010AMY (<jats:italic>p<\/jats:italic>\u2009=\u2009.025), whereas there was no significant differences between the AUCs for 2\u2009h\u2010TRY and 2\u2009h\u2010P\u2010AMY(<jats:italic>p<\/jats:italic>\u2009=\u2009.146), or between those for 2\u2009h\u2010TRY and 2\u2009h\u2010LIP (<jats:italic>p<\/jats:italic>\u2009=\u2009.792). The median increase ratio (expressed as a ratio relative to baseline) in TRY was highest among all of serum pancreatic enzymes tested immediately after ERCP (5.35, 1.72, 1.94, and 4.44 for TRY, AMY, P\u2010AMY, and LIP, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Measuring TRY immediately after ERCP is useful for the early prediction of PEP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.12063","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T07:34:55Z","timestamp":1724657695000},"page":"917-925","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Serum trypsin as an early predictor of post\u2010endoscopic retrograde cholangiopancreatography pancreatitis"],"prefix":"10.1002","volume":"31","author":[{"given":"Takashi","family":"Tamura","sequence":"first","affiliation":[{"name":"Second Department of Internal Medicine Wakayama Medical University  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiko","family":"Ashida","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine Wakayama Medical University  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoya","family":"Emori","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Wakayama Rosai Hospital  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Itonoga","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine Wakayama Medical University  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunobu","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine Wakayama Medical University  Wakayama 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