{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:10:52Z","timestamp":1790237452269,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP16ck0106079"],"award-info":[{"award-number":["JP16ck0106079"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP17ck0106350"],"award-info":[{"award-number":["JP17ck0106350"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>S\u20101, an oral fluoropyrimidine derivative, is standard adjuvant therapy for resected biliary tract cancer (BTC), based on the results of the JCOG1202, a phase III trial evaluating the survival benefit with adjuvant S\u20101 following curative resection for BTC compared to surgery alone. This multicenter ancillary study of the JCOG1202 aimed to evaluate the prognostic impact of the 5\u2010fluorouracil (5\u2010FU) metabolic pathway genes including thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The 5\u2010FU metabolic pathway genes were measured in tumor cells from formalin\u2010fixed paraffin\u2010embedded resected specimens from 183 patients (surgery alone: <jats:italic>n<\/jats:italic>\u2009=\u200994; adjuvant S\u20101: <jats:italic>n<\/jats:italic>\u2009=\u200989). We randomly divided them into training (<jats:italic>n<\/jats:italic>\u2009=\u200996) and validation sets (<jats:italic>n<\/jats:italic>\u2009=\u200987) for evaluating the interaction between gene levels and RFS benefits in the treatment arm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>RFS benefits of adjuvant S\u20101 were observed in the low DPD (HR\u2009=\u20090.440 and 0.748, respectively in the training and validation sets) and the low TP groups (HR\u2009=\u20090.709 and 0.602, respectively). Clinicopathological characteristics were well balanced between low and high DPD populations. More advanced stage tumors were observed in high TP populations as compared to those in low TP populations (<jats:italic>p<\/jats:italic>\u2009=\u2009.0332).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results suggest the RFS benefit of adjuvant S\u20101 in resected BTC patients with low DPD and low TP gene expressions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.12071","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T14:48:00Z","timestamp":1727275680000},"page":"886-896","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["5\u2010Fluorouracil metabolic pathway genes predict recurrence risk following adjuvant S\u20101 therapy: Results of an ancillary analysis from a phase III trial of resected biliary tract cancer (JCOG1202A1)"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9496-3278","authenticated-orcid":false,"given":"Shuichi","family":"Mitsunaga","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Oncology National Cancer Center Hospital East  Kashiwa Japan"},{"name":"Division of Biomarker Discovery, Exploratory Oncology Research and Clinical Trial Center National Cancer Center  Kashiwa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Oncology National Cancer Center Hospital East  Kashiwa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Nomura","sequence":"additional","affiliation":[{"name":"JCOG Data Center\/Operations Office National Cancer Center Hospital  Tokyo 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