{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:49:34Z","timestamp":1789778974842,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The impact of extrapancreatic infections (EPI) on outcomes of acute pancreatitis has received limited attention in the literature. We compiled data from published studies to present high\u2010quality evidence on the prognostic role of EPI on acute pancreatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This PRISMA\u2010compliant and PROSPERO registered review (CRD42024516872) searched Embase, Scopus, Web of Science, and PubMed for comparative studies between EPI and no\u2010EPI. Outcomes assessed were mortality, intensive care unit (ICU) admission, necrosis, organ failure, persistent organ failure, and length of hospital stay (LOS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven studies were included in the review. The meta\u2010analysis found that patients with EPI had a significantly higher risk of mortality as compared to the no\u2010EPI group (OR: 3.85 95% CI: 2.79, 5.31). The risk of ICU admission (OR: 12.24 95% CI: 3.56, 42.10), necrosis (OR: 3.50 95% CI: 1.37, 8.89) organ failure (OR: 6.03 95% CI: 3.75, 9.70) and persistent organ failure (OR: 6.72 95% CI: 3.58, 12.62) was significantly increased in the EPI group compared to the non\u2010EPI group. The meta\u2010analysis also found significantly longer LOS in the EPI group (MD: 11.92 95% CI: 4.75, 19.08).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>EPI is associated with a worse prognosis in acute pancreatitis. EPI was associated with an increased risk of mortality, ICU admission, organ failure, and prolonged LOS. Limited number of studies and baseline confounding are drawbacks of current evidence which need to be rectified by future studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.12099","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T04:45:32Z","timestamp":1739508332000},"page":"350-359","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The impact of extra\u2010pancreatic infections on outcomes of acute pancreatitis: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"32","author":[{"given":"XueMin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology The First People's Hospital of Linping District  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6381-1286","authenticated-orcid":false,"given":"Ping","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First People's Hospital of Linping District  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YanFei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First People's Hospital of Linping District  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ShanShan","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First People's Hospital of Linping District  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.20317"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.09.043"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.1427"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2016.07.004"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2023.03.003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i38.13879"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0668-1"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13304-023-01488-6"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2014.09.010"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2021.105906"},{"key":"e_1_2_7_12_1","unstructured":"WellsG SheaB O'ConnellD PetersonJ WelchV LososM et\u00a0al.The Newcastle\u2010Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta\u2010Analyses.http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp. Accessed 30 Oct 2020"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/biom.12817"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e13131"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000001847"},{"key":"e_1_2_7_16_1","first-page":"38","article-title":"The impacts of infectious complications on outcomes in acute pancreatitis: a retrospective study","volume":"7","author":"Jiang X","year":"2020","journal-title":"Mil Med Res"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/gastro\/goy005"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12161"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.05.053"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2018.05.481"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-019-02214-w"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.881750"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000250414.09255.84"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6447"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000067684"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.17.s1.2.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2015.03.022"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.01.032"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2018.05.485"},{"key":"e_1_2_7_30_1","article-title":"Antibiotic therapy for prophylaxis against infection of pancreatic necrosis in acute pancreatitis","volume":"2010","author":"Villatoro E","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000520892"}],"container-title":["Journal of Hepato-Biliary-Pancreatic Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jhbp.12099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T14:18:36Z","timestamp":1752934716000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jhbp.12099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,14]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/jhbp.12099"],"URL":"https:\/\/doi.org\/10.1002\/jhbp.12099","archive":["Portico"],"relation":{},"ISSN":["1868-6974","1868-6982"],"issn-type":[{"value":"1868-6974","type":"print"},{"value":"1868-6982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,14]]},"assertion":[{"value":"2025-02-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}