{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T21:15:21Z","timestamp":1767906921945,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>High subcutaneous adipose tissue radiodensity (SATr), an indirect surrogate marker of adipose tissue quality, was associated with poor prognosis in various cancers. The present study aimed to assess the association of SATr with survival outcomes in patients with advanced biliary tract cancer (BTC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective, single\u2010center study included patients with unresectable or recurrent BTC who underwent chemotherapy\/chemoradiotherapy. Overall survival (OS) and progression\u2010free survival (PFS) were assessed using the log\u2010rank test and the Cox proportional hazards model according to the SATr status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study cohort included 234 patients, including 38 and 196 patients with high and non\u2010high SATr, respectively. The median OS durations were 10.5 and 17.4\u2009months (HR\u2009=\u20091.72, 95% CI: 1.19\u20132.49, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01) and the median PFS durations were 4.9 and 8.0\u2009months (HR\u2009=\u20091.52, 95% CI: 1.05\u20132.20, <jats:italic>p<\/jats:italic>\u2009=\u2009.03) in patients with high and non\u2010high SATr, respectively. By multivariate analysis, high SATr, neutrophil\/lymphocyte ratio &gt;5, modified Glasgow prognostic score 1\u20132, and serum carcinoembryonic antigen &gt;5.0\u2009ng\/mL were predictors for OS (HR, 1.66, 2.42, 2.00, and 1.56, respectively; <jats:italic>p\u2009&lt;<\/jats:italic>\u2009.05). By multivariate analysis, metastatic disease status, high SATr, neutrophil\/lymphocyte ratio &gt;5, and modified Glasgow prognostic score 1\u20132 were independent risk factors for worse PFS (HR, 1.56, 1.56, 1.81, and 1.57, respectively; <jats:italic>p\u2009&lt;<\/jats:italic>\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High SATr was associated with risk of tumor progression and poor prognosis in patients with advanced BTC treated by palliative chemotherapy\/chemoradiotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.12105","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T02:39:50Z","timestamp":1736390390000},"page":"194-202","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Subcutaneous adipose tissue radiodensity as a predictor of poor prognosis in advanced biliary tract cancer"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4156-8025","authenticated-orcid":false,"given":"Ryo","family":"Sugiura","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hokkaido University Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Kawamoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hokkaido University Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0265-6068","authenticated-orcid":false,"given":"Masaki","family":"Kuwatani","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hokkaido University Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumichi","family":"Kawakubo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hokkaido University Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Harada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hokkaido University Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatsugu","family":"Ohara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hokkaido University Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Yonemura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hokkaido University Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunichiro","family":"Nozawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hokkaido University Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hokkaido University Hospital  Sapporo 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