{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T04:11:36Z","timestamp":1745986296109,"version":"3.40.4"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This network meta\u2010analysis (NMA) aims to provide evidence\u2010based guidance for selecting the second\u2010line chemotherapy for biliary tract cancer (BTC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive literature search was conducted on PubMed, Cochrane, and EMBASE through July 2024. Inclusion criteria involved: (1) patients underwent second\u2010line chemotherapy following platinum\u2010based first\u2010line therapy, (2) intervention\/comparator groups consisted of various chemotherapeutic agents, and (3) outcomes measured as hazard ratio (HR) of overall survival (OS) and progression\u2010free survival (PFS) in randomized controlled trials (RCTs) and cohort studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Outcomes were measured as HR of OS and PFS in RCTs and cohort studies. The eight studies consisting of 1621 patients were selected. In the NMA for OS, 5FU_plus_Plat (fluorouracil plus oxaliplatin or cisplatin; HR 0.52, 95% confidence interval [CI]: 0.30\u20130.91), nal\u2010IRI_5FU_LV (nano\u2010liposomal irinotecan plus fluorouracil and LV; HR 0.54 [95% CI: 0.32\u20130.92]), and FOLFOX (fluorouracil plus oxaliplatin; HR 0.69 [95% CI: 0.50\u20130.96]) demonstrated significant benefits in OS when compared to control. For PFS, nal\u2010IRI_5FU_LV (HR 0.61 [95% CI: 0.44\u20130.85]) provided a significant advantage over 5FU.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Second\u2010line chemotherapy for BTC after the failure of gemcitabine plus platinum as first\u2010line therapy, nal\u2010IRI_5FU_LV appears to be the most promising second\u2010line therapy in terms of both OS and PFS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.12113","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T08:20:31Z","timestamp":1737361231000},"page":"265-275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The efficacy of second\u2010line chemotherapy for advanced biliary tract cancer: A systematic review and network meta\u2010analysis"],"prefix":"10.1002","volume":"32","author":[{"given":"Inhwan","family":"Hwang","sequence":"first","affiliation":[{"name":"Department of Oncology, Daejeon Eulji Medical Center Eulji University School of Medicine  Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangah","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Blood Management Services, Daejeon Eulji Medical Center Eulji University  Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Hun","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Daejeon Eulji Medical Center Eulji University  Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunhwa","family":"Ihm","sequence":"additional","affiliation":[{"name":"Department of Blood Management Services, Daejeon Eulji Medical Center Eulji University  Daejeon Korea"},{"name":"Department of Laboratory Medicine, Daejeon Eulji Medical Center Eulji University  Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taeho Greg","family":"Rhee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale School of Medicine  New Haven Connecticut USA"},{"name":"Department of Public Health Sciences University of Connecticut School of Medicine  Farmington Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4143-7383","authenticated-orcid":false,"given":"Sung Ryul","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, College of Medicine Konyang University  Daejeon Korea"},{"name":"Konyang Medical Data Research Group\u2010KYMERA Konyang University Hospital  Daejeon Korea"},{"name":"Myunggok Medical Research Center Konyang University Hospital  Daejeon 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