{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T16:20:08Z","timestamp":1754151608037,"version":"3.41.2"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>This study aimed to identify the significant factors associated with liver transplant\u2010free survival time in Japanese patients with large\u2010duct primary sclerosing cholangitis (PSC) by evaluating the association between various parameters and clinical scores at PSC diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This single\u2010center retrospective study investigated factors influencing liver transplant\u2010free survival in Japanese large\u2010duct PSC patients. Univariate analysis using log\u2010rank tests identified significant clinical parameters and scoring systems, which were further analyzed with multivariate Cox proportional hazards models to determine independent predictors of liver transplant\u2010free survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 77 patients with large\u2010duct PSC were included. The univariate analysis identified that age (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), serum albumin level (<jats:italic>p<\/jats:italic>\u2009=\u2009.024), Child\u2010Pugh score (<jats:italic>p<\/jats:italic>\u2009=\u2009.0012), albumin\u2010bilirubin score (<jats:italic>p<\/jats:italic>\u2009=\u2009.0083), Amsterdam\u2010Oxford PSC score (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), and revised Mayo risk score (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) were significant predictors of liver transplant\u2010free survival time. However, the multivariate analysis revealed that only the Amsterdam\u2010Oxford PSC score remained as an independent factor significantly associated with liver transplant\u2010free survival time (hazard ratio: 12.90, 95% confidence interval: 2.78\u201359.81, <jats:italic>p<\/jats:italic>\u2009=\u2009.0011).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study underscored the importance of utilizing the Amsterdam\u2010Oxford PSC score in clinical practice to assess disease prognosis and guide patient management in Japanese patients with large\u2010duct PSC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.12117","type":"journal-article","created":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T05:43:16Z","timestamp":1740894196000},"page":"385-392","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic significance of clinical scoring systems for large\u2010duct primary sclerosing cholangitis in Japanese patients"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8134-8524","authenticated-orcid":false,"given":"Koji","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine Chiba University  Chiba Japan"},{"name":"Department of Medical Oncology, Graduate School of Medicine Chiba University  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Horio","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine Chiba University  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ohyama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine Chiba University  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoyasu","family":"Kan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine Chiba University  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayu","family":"Ouchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine Chiba University  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Nagashima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine Chiba University  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohichiroh","family":"Okitsu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine Chiba University  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izumi","family":"Ohno","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine Chiba University  Chiba Japan"},{"name":"Department of Medical Oncology, Graduate School of Medicine Chiba University  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine Chiba University  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/824168"},{"key":"e_1_2_8_3_1","first-page":"60","article-title":"Primary sclerosing cholangitis","volume":"31","author":"Siddiqui HM","year":"1988","journal-title":"Indian J Pathol 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