{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T12:25:02Z","timestamp":1780316702572,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chyle leak (CL) is a relevant complication of pancreatic surgery, but its incidence, risk factors, clinical and oncologic impacts, and nutritional relevance remain inconsistent and limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed patients who underwent pancreaticoduodenectomy for pancreatic head cancer from 2007 to 2023 at a single institution. The clinical impact of CL was evaluated by prolonged hospital stays and immune\u2010nutritional status, assessed using the Controlling Nutritional Status (CONUT) score at discharge. Oncologic impact included the administration of adjuvant chemotherapy, the surgery\u2010to\u2010chemotherapy interval, overall survival (OS), and recurrence\u2010free survival (RFS). Predictors of CL were identified through multivariate analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CL occurred in 70 patients (13.8%) and was significantly associated with prolonged hospital stay (OR: 1.947,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.045) and poor CONUT score at discharge (&gt;\u20096; OR: 1.820,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.036). CL did not significantly impact oncologic outcomes, including adjuvant chemotherapy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.732), surgery\u2010to\u2010chemotherapy interval (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.235), 5\u2010year OS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.978), or 5\u2010year RFS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.919). Independent predictors of CL included hypertension, lymph node metastasis, delayed gastric emptying, minimally invasive surgery (MIS), and operative time.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CL is associated with prolonged hospital stay and poor nutritional status at discharge, but shows no significant impact on long\u2010term oncologic outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jhbp.12191","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T07:57:03Z","timestamp":1755071823000},"page":"787-800","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comprehensive Analysis of Chyle Leak in Resected Pancreatic Head Cancer: Impact on Clinical, Oncologic, and Nutritional Outcomes"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1480-562X","authenticated-orcid":false,"given":"Jae Seung","family":"Kwak","sequence":"first","affiliation":[{"name":"Division of Hepatobiliary and Pancreas Surgery, Department of Surgery Yonsei University College of Medicine  Seoul Korea"},{"name":"Pancreatobiliary Cancer Center Yonsei Cancer Center, Severance Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5382-4658","authenticated-orcid":false,"given":"Chang Moo","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreas Surgery, Department of Surgery Yonsei University College of Medicine  Seoul Korea"},{"name":"Pancreatobiliary Cancer Center Yonsei Cancer Center, Severance Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4064-7776","authenticated-orcid":false,"given":"Ho Kyoung","family":"Hwang","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreas Surgery, Department of Surgery Yonsei University College of Medicine  Seoul Korea"},{"name":"Pancreatobiliary Cancer Center Yonsei Cancer Center, Severance Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7683-9687","authenticated-orcid":false,"given":"Sung Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreas Surgery, Department of Surgery Yonsei University College of Medicine  Seoul Korea"},{"name":"Pancreatobiliary Cancer Center Yonsei Cancer Center, Severance Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9913-8437","authenticated-orcid":false,"given":"Seung Soo","family":"Hong","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreas Surgery, Department of Surgery Yonsei University College of Medicine  Seoul Korea"},{"name":"Pancreatobiliary Cancer Center Yonsei Cancer Center, Severance Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.14701\/ahbps.22\u2010009"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.20485"},{"issue":"5","key":"e_1_2_8_4_1","first-page":"369","article-title":"Peri\u2010Operative Chylous Ascites","volume":"27","author":"Gaglio P. 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