{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T17:55:11Z","timestamp":1771955711820,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T00:00:00Z","timestamp":1754092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2025,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n We aimed to investigate the microbiological characteristics of pathogens isolated from blood cultures (BCs) of patients with acute cholangitis (AC) after biliary\u2010enteric anastomosis and biliary intervention (BI).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A retrospective analysis was conducted on 366 patients with AC and bacteremia between 2015 and 2024 at Hiroshima University Hospital. Patients were categorized into three groups: post\u2010biliary reconstruction\u2010associated AC (PBR\u2010AC), BI\u2010associated AC (BI\u2010AC), and common AC (C\u2010AC). Patients' clinical and microbiological data were statistically analyzed in each group.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The most frequently isolated pathogens were\n \n Escherichia coli<\/jats:italic>\n <\/jats:styled-content>\n and\n Klebsiella<\/jats:italic>\n spp., accounting for >\u200950% of isolates in all groups. ESCPM spp. (\n Enterobacter<\/jats:italic>\n spp., including\n \n Klebsiella aerogenes<\/jats:italic>\n <\/jats:styled-content>\n ,\n \n Serratia marcescens<\/jats:italic>\n <\/jats:styled-content>\n ,\n \n Citrobacter freundii<\/jats:styled-content>\n complex\n <\/jats:italic>\n ,\n Providencia<\/jats:italic>\n spp., and\n \n Morganella morganii<\/jats:italic>\n <\/jats:styled-content>\n ) were significantly associated with PBR\u2010 and BI\u2010AC compared with C\u2010AC. No significant differences in the prevalence of anaerobic bacteria were observed among the groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The prevalence of ESCPM spp. isolated from BCs was significantly higher in the PBR\u2010 and BI\u2010AC groups than in the C\u2010AC group. The presence of biliary\u2010enteric anastomosis or BI history should be checked when determining the treatment strategy for AC. Cefepime may be a better antibiotic option for PBR\u2010 and BI\u2010AC, particularly in severe cases.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jhbp.12193","type":"journal-article","created":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T07:19:14Z","timestamp":1754119154000},"page":"766-776","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Microbiological Characteristics of Pathogens Isolated From Blood Cultures of Patients With Acute Cholangitis: Insights From Patients With Biliary\u2010Enteric Anastomosis"],"prefix":"10.1002","volume":"32","author":[{"given":"Yuta","family":"Kuhara","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Hiroshima University Hospital Hiroshima Japan"},{"name":"Department of Surgery, Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1651-0091","authenticated-orcid":false,"given":"Hiroki","family":"Kitagawa","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Hiroshima University Hospital Hiroshima Japan"},{"name":"Department of Surgery, Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0800-4458","authenticated-orcid":false,"given":"Yuki","family":"Kaiki","sequence":"additional","affiliation":[{"name":"Department of Surgery, Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keitaro","family":"Omori","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Hiroshima University Hospital Hiroshima 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