{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:22:15Z","timestamp":1747149735349,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In this study, we aimed to develop and validate a nomogram to predict overall survival (OS) and recurrence\u2010free survival (RFS) in patients who underwent curative resection of ampulla of Vater (AOV) cancer. This is the first study for nomograms in AOV cancer patients using retrospective data based on an international multicenter study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 2007 patients with AOV adenocarcinoma who received operative therapy between 2002 January and 2015 December in Korea and Japan were retrospectively assessed to develop a prediction model. Nomograms for 5\u2010year OS and 3\u2010year RFS were constructed by dividing the patients who received and who did not receive adjuvant therapy after surgery, respectively. Significant risk factors were identified by univariate and multivariate Cox analyses. Performance assessment of the four prediction models was conducted by the Harrell\u2019s concordance index (C\u2010index) and calibration curves using bootstrapping.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 2007 and 1873 patients were collected for nomogram construction to predict 5\u2010year OS and 3\u2010year RFS. We developed four types of nomograms, including models for 5\u2010year OS and 3\u2010year RFS in patients who did not receive postoperative adjuvant therapy, and 5\u2010year OS and 3\u2010year RFS in patients who received postoperative adjuvant therapy. The C\u2010indices of these nomograms were 0.795 (95% confidence interval [CI]: 0.766\u20100.823), 0.712 (95% CI: 0.674\u20100.750), 0.804 (95% CI: 0.7778\u20100.829), and 0.703 (95% CI: 0.669\u20100.737), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This predictive model could help clinicians to choose optimal treatment and precisely predict prognosis in AOV cancer patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.1229","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T07:05:28Z","timestamp":1661238328000},"page":"360-373","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Proposal of nomograms to predict clinical outcomes in patients with ampulla of Vater cancer based on the Korea\u2010Japan collaborative study"],"prefix":"10.1002","volume":"30","author":[{"given":"Hyung Sun","family":"Kim","sequence":"first","affiliation":[{"name":"Pancreatobiliary Cancer Clinic, Department of Surgery, Gangnam Severance Hospital Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woojin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Preventive medicine Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5520-8114","authenticated-orcid":false,"given":"Itaru","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Yokohama City University School of Medicine  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Young","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer Research Institute Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1595-0135","authenticated-orcid":false,"given":"Hongbeom","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer Research Institute Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5422-5481","authenticated-orcid":false,"given":"Ki Byung","family":"Song","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Surgery Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1749-038X","authenticated-orcid":false,"given":"Dae Wook","family":"Hwang","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Surgery Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5382-4658","authenticated-orcid":false,"given":"Chang Moo","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Severance Hospital Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4064-7776","authenticated-orcid":false,"given":"Ho Kyoung","family":"Hwang","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Severance Hospital Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang\u2010Jae","family":"Park","sequence":"additional","affiliation":[{"name":"Center for Liver and Pancreatobiliary cancer National Cancer Center  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung\u2010Sik","family":"Han","sequence":"additional","affiliation":[{"name":"Center for Liver and Pancreatobiliary cancer National Cancer Center  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoo\u2010Seok","family":"Yoon","sequence":"additional","affiliation":[{"name":"Seoul National University Bundang Hospital Seoul National University College of Medicine  Goyang South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae","family":"Do Yang","sequence":"additional","affiliation":[{"name":"Department of Surgery Jeonbuk National University hospital  Jeonju South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Amano","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic surgery Osaka City University Graduate School of Medicine  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadaaki","family":"Yamazoe","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic surgery Osaka City University Graduate School of Medicine  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Yanagimoto","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Hepato\u2010Biliary\u2010Pancreatic Surgery Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Ajiki","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Hepato\u2010Biliary\u2010Pancreatic Surgery Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Ohtsuka","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Graduate School of Medicine Chiba University  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Graduate School of Medicine Chiba University  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong\u2010Shik","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery Yeungnam University College of Medicine  Daegu South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Kitahata","sequence":"additional","affiliation":[{"name":"2nd Department of Surgery Wakayama medical university  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Amaya","sequence":"additional","affiliation":[{"name":"Department of Surgery Toyama Prefectural Central Hospital  Toyama 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