{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T22:18:59Z","timestamp":1772662739570,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In IgG4\u2010related sclerosing cholangitis (IgG4\u2010SC), the necessity of biliary drainage (BD) is unclear. In this study, we aimed to retrospectively investigate the improvement of liver damage and jaundice in cases of IgG4\u2010SC with and without BD, before starting steroids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 52 patients with IgG4\u2010SC were investigated in the study. The study endpoints were the normalization rate of alkaline phosphatase (ALP)\/total bilirubin (T\u2010Bil) after 8\u2009weeks of steroids, with and without BD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Propensity score matching was performed based on ALP and T\u2010Bil, and 28 patients were included. There were 14 patients each in the BD and non\u2010BD groups. Before initiation of steroids, the mean ALP in the BD group and the non\u2010BD group was 378\/461 (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.541); the mean T\u2010Bil was 2.5\/1.8 (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.401). Eight weeks after initiation of steroids, ALP improvement rate in the BD group\/non\u2010BD group was 69.2%\/61.5% (<jats:italic>P<\/jats:italic>\u00a0=\u00a01.000), and T\u2010Bil improvement rate was 100%\/100% (<jats:italic>P<\/jats:italic>\u00a0=\u00a0Ns).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Steroids for IgG4\u2010SC could prove effective in improving liver damage and jaundice, regardless of the presence or absence of BD. BD for IgG4\u2010SC aimed to improve jaundice may not be necessary.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.1230","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T07:10:04Z","timestamp":1661757004000},"page":"392-400","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Request for biliary drainage for IgG4\u2010SC could be waived before steroid administration?"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2482-6707","authenticated-orcid":false,"given":"Yusuke","family":"Kurita","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Yokohama City University Hospital  Yokohama 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