{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:59:42Z","timestamp":1792432782562,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T00:00:00Z","timestamp":1667520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100019127","name":"Nakayama Cancer Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019127","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To improve treatment outcomes in patients with colorectal liver metastasis (CRLM), the Joint Committee for Nationwide Survey on CRLM was established by the Japanese Society for Cancer of the Colon and Rectum and the Japanese Society of Hepato\u2010Biliary\u2010Pancreatic Surgery. The aim of the study was to evaluate transition in the characteristics and treatment strategy in CRLM patients and analyze prognostic factors using large\u2010scale data. The present study summarizes the data of patients newly diagnosed between 2015 and 2017 and presents prognostic data of patients newly diagnosed in 2013 and 2014. Survival curves were generated by the Kaplan\u2013Meier method and compared by log\u2010rank test. Multivariate analyses were carried out using Cox proportional hazard modeling. The data of 4502 patients newly diagnosed with CRLM between 2015 and 2017 and the prognostic data of 2427 patients diagnosed in 2013 and 2014 are included. Regarding the 2013 and 2014 prognostic data, the 5\u2010year overall survival (OS) rates of patients who underwent hepatectomy alone was 59.8%. Multivariate analyses identified age at diagnosis of CRLM \u226570\u2009years, concomitant extrahepatic metastasis at diagnosis of CRLM, tumor depth of primary lesion \u2265subserosa\/pericolic or perirectal tissue, mutant <jats:italic>KRAS<\/jats:italic> status, number of CRLM \u22655, maximum diameter of CRLM &gt;5\u2009cm, and surgical curability R1\/R2 as independent predictors of OS. Analysis of the latest nationwide database of patients diagnosed with CRLM revealed changes in patients and oncological characteristics, a transition in treatment strategy, and different independent prognosticators to those reported previously.<\/jats:p>","DOI":"10.1002\/jhbp.1252","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T06:56:47Z","timestamp":1666162607000},"page":"570-590","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Comprehensive data of 4502 patients newly diagnosed with colorectal liver metastasis between 2015 and 2017, and prognostic data of 2427 patients newly diagnosed with colorectal liver metastasis in 2013 and 2014: Third report of a nationwide survey in Japan"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6431-0011","authenticated-orcid":false,"given":"Katsunori","family":"Sakamoto","sequence":"first","affiliation":[{"name":"Joint Committee for Nationwide Survey on Colorectal Liver Metastasis  Bunkyo\u2010ku, Tokyo Japan"},{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic and Breast Surgery Ehime University Graduate School of Medicine  Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9046-0454","authenticated-orcid":false,"given":"Toru","family":"Beppu","sequence":"additional","affiliation":[{"name":"Joint Committee for Nationwide Survey on Colorectal Liver Metastasis  Bunkyo\u2010ku, Tokyo Japan"},{"name":"Department of Surgery Yamaga City Medical Center  Kumamoto 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