{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:57:56Z","timestamp":1789441076782,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study investigated submucosal alterations in biliary carcinogenesis of pancreaticobiliary maljunction (PBM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty\u2010three patients with PBM (including seven with gallbladder [GB] cancer), four with neither biliary tract cancer nor PBM who underwent pancreaticoduodenectomy (controls), and seven with chronic cholecystitis without PBM were enrolled. Protein expression of \u03b1\u2010smooth muscle actin (\u03b1SMA), CD68, and CD204 in the GB lamina propria and that of NLRP3 and caspase 1 in the GB epithelium and lamina propria were examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with the control and cholecystitis groups, \u03b1SMA expression was higher in the cancerous part (stroma) of the GB in patients with GB cancer\u2009+\u2009PBM and in the lamina propria of patients with PBM. The CD204\/CD68 ratio in the lamina propria was higher in the PBM group than in the control and cholecystitis groups. NLRP3 and caspase 1 expression in both the lamina propria and epithelium was higher in the PBM than control group. In the PBM group, NLRP3\u2010 and caspase 1\u2010positive cells in the lamina propria were located near the epithelium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Activated fibroblasts and M2 macrophages in the GB lamina propria may be associated with biliary carcinogenesis of PBM, possibly through inflammasome activation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jhbp.1253","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T03:04:59Z","timestamp":1666148699000},"page":"462-472","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Characteristic submucosal alteration in biliary carcinogenesis of pancreaticobiliary maljunction with a focus on inflammasome activation"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4948-3413","authenticated-orcid":false,"given":"Shoko","family":"Yamashita","sequence":"first","affiliation":[{"name":"Department of Surgery Tokushima University  Kuramoto\u2010cho, Tokushima Japan"},{"name":"Department of Pathology and Laboratory Medicine Tokushima University  Kuramoto\u2010cho, Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chie","family":"Takasu","sequence":"additional","affiliation":[{"name":"Department of Surgery Tokushima University  Kuramoto\u2010cho, Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Morine","sequence":"additional","affiliation":[{"name":"Department of Surgery Tokushima University  Kuramoto\u2010cho, Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Ishibashi","sequence":"additional","affiliation":[{"name":"Department of Surgery Tokushima University  Kuramoto\u2010cho, Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Ikemoto","sequence":"additional","affiliation":[{"name":"Department of Surgery Tokushima University  Kuramoto\u2010cho, Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Surgery Tokushima University  Kuramoto\u2010cho, Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3847-751X","authenticated-orcid":false,"given":"Shinichiro","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Surgery Tokushima University  Kuramoto\u2010cho, Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Oya","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology Tokushima University  Kuramoto\u2010cho, Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Tsuneyama","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Tokushima University  Kuramoto\u2010cho, Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuo","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Surgery Tokushima University  Kuramoto\u2010cho, Tokushima 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