{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T11:23:08Z","timestamp":1778152988287,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T00:00:00Z","timestamp":1668643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Induction of liver regeneration represents an option to expand the resectability in patients with expected small future liver remnant (FLR). The aim of this cohort\u2010study is to compare the liver regeneration between different surgical procedures, including novel procedures such as two\u2010stage living donor liver transplantation using small\u2010for\u2010size grafts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010three patients with colorectal liver metastases were included between 2004 and 2020. They underwent one of the following three procedures: portal vein embolization (PVE), associated liver partition with portal vein ligation for staged hepatectomy (ALPPS), and living donor two\u2010stage liver transplantation (LT). The volume gain of the future liver remnant was analyzed in comparison between the three mentioned procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The type of surgery performed had a significant correlation with liver regeneration with a strong effect on the benefit of ALPPS and liver transplantation, respectively (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.6, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.00003). The type of surgery was the only independent co\u2010factor in the multiple regression, which showed a significant influence on FLR\u2010increase favoring two\u2010stage transplantation compared to the other two related procedures (<jats:italic>\u00df<\/jats:italic>\u00a0=\u00a0.12, <jats:italic>T<\/jats:italic>\u00a0=\u00a03.9, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0004). The histological and immunohistochemical studies also showed a clear advantage of proliferation to the benefits of two\u2010stage liver transplantation compared with ALPPS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Two\u2010stage liver transplantation using small\u2010for\u2010size grafts induces better FLR\u2010increase than portal vein embolization or ALPPS in patients with colorectal liver metastases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.1266","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T06:49:48Z","timestamp":1667976588000},"page":"615-624","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Liver regeneration after two\u2010stage liver transplantation is more effective than after other preconditioning procedures in colorectal liver 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