{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:58:09Z","timestamp":1787731089696,"version":"build-2784847793"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100018553","name":"Science and Technology Plan Project of Wenzhou, China","doi-asserted-by":"publisher","award":["Y20210229"],"award-info":[{"award-number":["Y20210229"]}],"id":[{"id":"10.13039\/501100018553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The incidence of acute pancreatitis caused by hyperlipidaemia is increasing. A quick and easy diagnosis of the severity of hyperlipidaemic acute pancreatitis (HTGP) is important to improve patient prognosis and reduce mortality. Previous studies reported that insulin resistance (IR) is associated with acute pancreatitis. Our study aimed to investigate the correlation between the triglycerides to high\u2010density lipoprotein cholesterol (TG\/HDL\u2010C) ratio and HTGP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients' laboratory and clinical parameters were obtained from the institutional pancreatitis database. Univariate and multivariate logistic regression analyses were applied to evaluate the risk factors for the severity of HTGP and the efficacy of four clinical scoring systems: Ranson's Criteria, Acute Physiology and Chronic Health Evaluation II (APACHE II), the Bedside Index for Severity in Acute Pancreatitis (BISAP), and Marshall.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 290 patients, 134 (46.2%) were diagnosed with moderately severe\u00a0to\u00a0severe HTGP. The TG\/HDL\u2010C ratio was higher in the moderately severe to severe HTGP subgroup than in the mild HTGP subgroup. Among the independent risk factors, such as amylase, albumin, aspartate transaminase (AST), systemic inflammatory response syndrome (SIRS), and TG\/HDL\u2010C ratio, the TG\/HDL\u2010C ratio had the highest area under the curve (AUC) (0.727, 95% CI, 0.571\u20130.701). In comparison with other clinical scoring systems, the TG\/HDL\u2010C ratio has a relatively preferable predictive ability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that the TG\/HDL\u2010C ratio is positively correlated with HTGP severity and could be used as a simple indicator of severe HTGP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.1281","type":"journal-article","created":{"date-parts":[[2022,11,20]],"date-time":"2022-11-20T14:49:57Z","timestamp":1668955797000},"page":"784-791","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Triglycerides to high\u2010density lipoprotein cholesterol (<scp>TG<\/scp>\/<scp>HDL\u2010C<\/scp>) ratio is an independent predictor of the severity of hyperlipidaemic acute pancreatitis"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5099-3803","authenticated-orcid":false,"given":"Yingbao","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of the First Clinical Medical Sciences Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Peng","sequence":"additional","affiliation":[{"name":"School of the First Clinical Medical Sciences Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weizhi","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huajun","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Surgery The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuzhi","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9300-0840","authenticated-orcid":false,"given":"Na","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12]]},"reference":[{"issue":"4","key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.pan.2013.07.063","article-title":"IAP\/APA evidence\u2010based guidelines for the management of acute pancreatitis","volume":"13","author":"I.A.P.A.P.A.A.P.G. 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