{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T21:44:21Z","timestamp":1758923061484,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004921","name":"Shanghai Jiao Tong University","doi-asserted-by":"publisher","award":["YG2016MS47"],"award-info":[{"award-number":["YG2016MS47"]}],"id":[{"id":"10.13039\/501100004921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["202040289"],"award-info":[{"award-number":["202040289"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to distinguish between cholesterol and neoplastic gallbladder polyps using dynamic contrast\u2010enhanced CT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The dataset retrospectively comprised 222 cases, including 106 cases of cholesterol polyps and 116 cases of neoplastic polyps (59 adenoma and 57 adenocarcinoma). The perception and Hounsfield units of the polyps and gallbladder bile were assessed by contrast\u2010enhanced CT, and the polyp\u2010to\u2010bile ratio (PBR) was calculated. Receiver operating characteristic (ROC) curves and area under the curve analyses were used to assess the diagnostic value of the diameter and PBR for neoplastic polyps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The diameter of cholesterol polyps was significantly smaller than that of neoplastic polyps. The proportion of perceived cholesterol polyps in the plain and arterial phases of CT were significantly lower than those of neoplastic polyps (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). On the contrary, the CT values of gallbladder bile of cholesterol polyps were always significantly higher than those of neoplastic polyps (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). The median PBR values of cholesterol polyps were significantly lower than those of neoplastic polyps (<jats:italic>p<\/jats:italic>\u00a0\u2264\u00a0.001). ROC analysis showed that diameter and a plain phase PRB had better diagnostic value for neoplastic polyps. Polyp diameter\u2009\u2265\u200911.95\u2009mm and the plain phase PBR \u22651.48 were the optimal cut\u2010off values for diagnosis of neoplastic polyps. Combining a diameter\u2009\u2265\u200912\u2009mm and a PBR in the plain phase \u22651.48 further improved neoplastic polyp diagnostic specificity and positive likelihood ratio (10.453).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Polyp\u2010to\u2010bile ratio in contrast\u2010enhanced CT scanning is a new and convenient index for identifying cholesterol and neoplastic gallbladder polyps.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.1300","type":"journal-article","created":{"date-parts":[[2022,12,18]],"date-time":"2022-12-18T07:58:43Z","timestamp":1671350323000},"page":"904-913","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Combining polyp diameter and polyp\u2010to\u2010bile ratio by dynamic contrast\u2010enhanced <scp>CT<\/scp> scanning can improve the diagnostic specificity of gallbladder neoplastic polyps"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6480-1873","authenticated-orcid":false,"given":"Qiwei","family":"Li","sequence":"first","affiliation":[{"name":"Department of General Surgery, Renji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunwang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Biliary\u2010Pancreatic Surgery, Renji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqing","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Renji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunhe","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Shanghai East Hospital Tongji University of School Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Renji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijun","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Radiology, Renji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianrong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Renji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanyan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Clinical Research Institute Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pathology, Renji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biliary\u2010Pancreatic Surgery, Renji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2017.1372188"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2016.57.6.1370"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.05071.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-017-3476-0"},{"key":"e_1_2_10_6_1","first-page":"365","article-title":"Routine histopathological study of cholecystectomy specimens. 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