{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:22:26Z","timestamp":1747149746259,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Purpose<\/jats:title><jats:p>This experimental study in rats aimed to investigate the impact of very early introduction (within 3\u00a0h) of everolimus (EVR)\u2009+\u2009reduced\u2010tacrolimus (TAC) after partial liver transplantation (LT) on liver regeneration, rejection, and survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Based on appropriate dose of EVR\u2009+\u2009reduced\u2010TAC in 70% hepatectomy (Experiment 1), allogeneic 30% partial LT (Experiment 2) and whole LT (Experiment 3) were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After partial LT in EVR\u2009+\u2009reduced\u2010TAC therapy, restoration of liver graft weight (to that of the whole liver) was delayed compared with standard dose TAC monotherapy (standard\u2010TAC) on day 3 (59.3% vs. 72.9%; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and 14 (88.1% vs. 95.5%; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01). Survival was 75%, which was not as high as the value of 100% observed for standard\u2010TAC, because neither infection nor rejection could be prevented. By contrast, survival after whole LT was 100% as neither infection nor rejection occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The very early introduction of EVR\u2009+\u2009reduced\u2010TAC after partial LT delayed liver regeneration, and made it difficult to manage the dose required to suppress both infection and rejection. On the other hand, EVR\u2009+\u2009reduced\u2010TAC could be introduced safely very early after whole LT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.1310","type":"journal-article","created":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T00:39:18Z","timestamp":1674866358000},"page":"882-892","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of very early introduction of everolimus on liver regeneration after partial liver transplantation in rats"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4248-3568","authenticated-orcid":false,"given":"Masaaki","family":"Hirata","sequence":"first","affiliation":[{"name":"Department of Surgery, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shintaro","family":"Yagi","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic Surgery and Transplantation Kanazawa University  Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Surgery, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Masano","sequence":"additional","affiliation":[{"name":"Department of Surgery, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Miyachi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6770-5297","authenticated-orcid":false,"given":"Siyuan","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Surgery, 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