{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:11:12Z","timestamp":1761919872523},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,8,3]],"date-time":"2014-08-03T00:00:00Z","timestamp":1407024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cholangiocarcinoma has been reported in workers exposed to chlorinated organic solvents and has consequently been classified as an occupational disease (occupational cholangiocarcinoma) by the <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>inistry of <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ealth, <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>abour and <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>elfare. This study aimed to identify the characteristics of nine workers newly diagnosed with occupational cholangiocarcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was a retrospective study conducted in 13 hospitals and three universities. Clinicopathological findings of nine occupational cholangiocarcinoma patients from seven printing companies in <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apan were investigated and compared with 17 cholangiocarcinoma patients clustered in a single printing company in <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>saka.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patient age at diagnosis was 31\u201357 years. Patients were exposed to 1,2\u2010dichloropropane and\/or dichloromethane. Serum \u03b3\u2010glutamyl transpeptidase activity was elevated in all patients. Regional dilatation of the intrahepatic bile ducts without tumor\u2010induced obstruction was observed in two patients. Four patients developed intrahepatic cholangiocarcinoma and five developed hilar cholangiocarcinoma. Biliary intraepithelial neoplasia and\/or intraductal papillary neoplasm of the bile duct was observed in four patients with available operative or autopsy specimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Most of these patients with occupational cholangiocarcinoma exhibited typical findings, including high serum \u03b3\u2010glutamyl transpeptidase activity, regional dilatation of the bile ducts, and precancerous lesions, similar to findings previously reported in 17 occupational cholangiocarcinoma patients in <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>saka.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.137","type":"journal-article","created":{"date-parts":[[2014,8,4]],"date-time":"2014-08-04T00:32:56Z","timestamp":1407112376000},"page":"809-817","source":"Crossref","is-referenced-by-count":35,"title":["Characteristics of printing company workers newly diagnosed with occupational cholangiocarcinoma"],"prefix":"10.1002","volume":"21","author":[{"given":"Shoji","family":"Kubo","sequence":"first","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic Surgery Osaka City University Graduate School of Medicine  1\u20104\u20103 Asahimachi, Abeno\u2010ku Osaka 545\u20108585 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic Surgery Osaka City University Graduate School of Medicine  1\u20104\u20103 Asahimachi, Abeno\u2010ku Osaka 545\u20108585 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigekazu","family":"Takemura","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic Surgery Osaka City University Graduate School of Medicine  1\u20104\u20103 Asahimachi, Abeno\u2010ku Osaka 545\u20108585 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Surgery Nippon University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Division of Hepato\u2010Biliary\u2010Pancreatic Surgery Department of Surgery Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiaki","family":"Unno","sequence":"additional","affiliation":[{"name":"Division of Hepato\u2010Biliary\u2010Pancreatic Surgery Department of Surgery Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Hijioka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Aichi Cancer Center Hospital  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihisa","family":"Fujiyoshi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology 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