{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:29:14Z","timestamp":1791973754998,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:00:00Z","timestamp":1696464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Staging laparoscopy (SL) has been advocated for pancreatic cancer, mainly to evaluate the peritoneal washing cytology (CY) status, which seems to impact the prognosis of pancreatic cancer. To establish an optimal treatment strategy for CY positive (CY+) pancreatic cancer cases, real\u2010world clinical data about CY status\u2010depending surgical outcomes should be accumulated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Peritoneal washing samples were collected from 183 consecutive patients who could be classified as either resectable or borderline resectable (BR) pancreatic cancer between January 2012 and December 2020. Correlations between the CY status and other clinicopathological parameters with the recurrence patterns and survival outcomes were examined. In addition, we analyzed several risk factors for the CY+ status and attempted to identify the patient population that may benefit most from SL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 24 of the 183 patients were CY+. Peritoneal recurrence occurred more frequently in CY+ cases than in CY\u2212 cases (29% vs. 6%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and median survival time after surgery was significantly shorter in CY+ cases than in CY\u2212 cases (28.5\u2009months vs. 67.5\u2009months; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). In detail, almost all CY+ patients among curative resection\u2010intended cases had either elevated preoperative serum CA19\u20109 levels (\u2265250\u2009U\/mL) or DUPAN\u20102 levels (\u2265150\u2009U\/mL). Significant predictive factors of CY positivity were BR status (<jats:italic>p<\/jats:italic>\u2009=\u2009.028) and serum CA19\u20109 level exceeding 250\u2009U\/mL (<jats:italic>p<\/jats:italic>\u2009=\u2009.008).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CY status was identified as an independent prognostic factor, and SL examination should be recommended, especially for patients with risk factors for CY positivity, such as BR cancer and elevated serum CA19\u20109 levels.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.1373","type":"journal-article","created":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T17:38:11Z","timestamp":1696613891000},"page":"1273-1281","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Predictive impacts of peritoneal washing cytology for surgical resection\u2010intended pancreatic cancer cases: Establishment of planned staging laparoscopy criteria"],"prefix":"10.1002","volume":"30","author":[{"given":"Nobutake","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Gastroenterological Surgery Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3294-0168","authenticated-orcid":false,"given":"Hideki","family":"Takami","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6875-2303","authenticated-orcid":false,"given":"Masamichi","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshikuni","family":"Inokawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Kurimoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norifumi","family":"Hattori","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuro","family":"Kanda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chie","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goro","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Kodera","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21654"},{"key":"e_1_2_7_3_1","unstructured":"Cancer Statistics.Cancer Information Service National Cancer Center Japan (Vital Statistics of Japan Ministry of Health Labour and Welfare).2021."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.61005"},{"key":"e_1_2_7_5_1","unstructured":"Kanehara & Co L. Japan Pancreas Society.General Rules for the Study of Pancreatic Cancer. 7th ed. Tokyo Japan; 2016."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9307"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1011923"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1304369"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001705"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.447"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.11792"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-022-06049-7"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2019.06.023"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-014-2637-7"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2022.12.011"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-020-02121-4"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasc.2020.05.015"},{"issue":"6","key":"e_1_2_7_18_1","first-page":"611","article-title":"Optimal surgical strategy for potentially curable serosa\u2010involved gastric carcinoma with intraperitoneal free cancer cells","volume":"184","author":"Wu CC","year":"1997","journal-title":"J Am Coll Surg"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-017-3470-6"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2010.05.015"},{"key":"e_1_2_7_21_1","first-page":"474","article-title":"Efficacy and economic aspects of preoperative diagnosis: laparoscopy is useful in only 13% of patients with pancreatic carcinoma","volume":"114","author":"Friess H","year":"1997","journal-title":"Langenbecks Arch Chir Suppl Kongressbd"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-015-0270-x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2020.07.405"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-017-7215-0_15"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-012-1859-9"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2018.08.003"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005395"},{"issue":"3","key":"e_1_2_7_28_1","first-page":"128","article-title":"High serum levels of DUPAN2 antigen and CA19\u20109 in pancreatic cancer: correlation with immunocytochemical localization of antigens in cancer cells","volume":"35","author":"Suzuki Y","year":"1988","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.1245"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.1045"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.1184"}],"container-title":["Journal of Hepato-Biliary-Pancreatic Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jhbp.1373","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T20:52:57Z","timestamp":1700081577000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jhbp.1373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,5]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1002\/jhbp.1373"],"URL":"https:\/\/doi.org\/10.1002\/jhbp.1373","archive":["Portico"],"relation":{},"ISSN":["1868-6974","1868-6982"],"issn-type":[{"value":"1868-6974","type":"print"},{"value":"1868-6982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,5]]},"assertion":[{"value":"2023-10-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}