{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T14:25:51Z","timestamp":1777991151576,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T00:00:00Z","timestamp":1698883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is still little knowledge about the outcomes of laparoscopic liver resection (LLR) for multiple hepatocellular carcinomas (HCC). The aim of this study was to assess the short\u2010 and long\u2010 term outcomes of LLR versus open liver resection (OLR) for patients with multiple HCC within and beyond the Milan criteria, and in both BCLC\u2010A and \u2010B stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data regarding all consecutive patients undergoing liver resection for multiple HCC were retrospectively collected from Asian (South Korean) and European (Italian) referral HPB centers. The cases were propensity\u2010score matched for age, BMI, center, extent of the resection, postero\u2010superior location of the lesion, underlying liver condition, BCLB staging and the Milan criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 203 patients were included in the study: 27% of patients had undergone hemi\u2010hepatectomy, 26.6% atypical resections, 20.6% sectionectomy and 16.2% segmentectomy. After PSM two cohorts of 57 patients were obtained, with no significant differences in all preoperative characteristics. The length of hospital stay was significantly lower after LLR (median 7 vs. 9\u2009days, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01), with no statistically significant differences in estimated blood loss, operation time, transfusions, postoperative bile leak, ascites, severe complications and R1 resection rates. After a median follow\u2010up of 61 (\u00b17) months, there were no significant differences between OLR and LLR in both median OS (69 vs. 59\u2009months, <jats:italic>p<\/jats:italic>\u2009=\u2009.74, respectively) and median DFS (12 vs. 10\u2009months, <jats:italic>p<\/jats:italic>\u2009=\u2009.48, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LLR for multiple HCC can be safe and effective in selected cases and is able to shorten median hospital stay without affecting perioperative and long\u2010term oncological outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.1384","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T08:47:04Z","timestamp":1698914824000},"page":"2-11","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Laparoscopic versus open liver resection for multiple hepatocellular carcinoma within and beyond the Milan criteria: An <scp>Eastern\u2010Western<\/scp> propensity score\u2013matched analysis"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9185-2054","authenticated-orcid":false,"given":"Gianluca","family":"Cassese","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine and Surgery, Division of Minimally Invasive and Robotic Hepato\u2010Pancreato\u2010Biliary Surgery, and Transplantation Service Federico II University Hospital  Naples Italy"},{"name":"Department of Surgery, Division of Hepato\u2010Pancreato\u2010Biliary Surgery Seoul National University Bundang Hospital  Seongnam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9659-1260","authenticated-orcid":false,"given":"Ho\u2010Seong","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Hepato\u2010Pancreato\u2010Biliary Surgery Seoul National University Bundang Hospital  Seongnam South 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Young","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Hepato\u2010Pancreato\u2010Biliary Surgery Seoul National University Bundang Hospital  Seongnam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Montalti","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery, Division of Minimally Invasive and Robotic Hepato\u2010Pancreato\u2010Biliary Surgery, and Transplantation Service Federico II University Hospital  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto Ivan","family":"Troisi","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery, Division of Minimally Invasive and Robotic Hepato\u2010Pancreato\u2010Biliary Surgery, and Transplantation Service Federico II University Hospital  Naples 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