{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T19:14:10Z","timestamp":1783624450594,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K09163"],"award-info":[{"award-number":["19K09163"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sarcopenia is a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength. As reported in previous studies, the loss of skeletal muscle mass is associated with poor liver regeneration after hepatectomy. It is considered important to clarify the effect of sarcopenia on liver regeneration; however, there are no reports about model animals for sarcopenia. We focused on the peroxisome proliferator\u2010activated receptor\u2010gamma coactivator\u20101alpha (PGC\u20101\u03b1) transgenic mice that overexpressed PGC\u20101\u03b1, specifically for skeletal muscle, and showed significant atrophy of type 2B fiber\u2010rich muscles like sarcopenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed 70% hepatectomy using PGC\u20101\u03b1 transgenic mice and examined the liver regeneration rate and the effects of branched\u2010chain amino acids (BCAA) after hepatectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Liver regeneration after 70% hepatectomy was significantly suppressed in the PGC\u20101\u03b1 transgenic mice. In addition, a decrease in the blood BCAA concentration and a decrease in the liver glycogen content after 70% hepatectomy were observed in the PGC\u20101\u03b1 transgenic mice. By administering BCAA before and after surgery, it was clarified that a significant increase in the blood BCAA concentration was observed and the liver regeneration rate was improved in the PGC\u20101\u03b1 transgenic mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>BCAA administration may improve the suppression of liver regeneration in patients with sarcopenia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.1386","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T09:34:14Z","timestamp":1698831254000},"page":"152-161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Liver regeneration after hepatectomy is significantly suppressed in a muscular atrophy mouse model"],"prefix":"10.1002","volume":"31","author":[{"given":"Kei","family":"Hagiwara","sequence":"first","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Surgery, Department of 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