{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:59:51Z","timestamp":1792432791388,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:00:00Z","timestamp":1698364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the prognostic impact of <jats:italic>RAS<\/jats:italic> mutations on the Japanese Society of Hepatobiliary and Pancreatic Surgeons (JSHBPS) nomogram score in patients with colorectal cancer liver metastasis (CRLM) following hepatectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 218 consecutive patients undergoing hepatectomy for CRLM between 2004 and 2020. The JSHBPS nomogram score was calculated using six preoperative clinical factors. The score ranged from 0 to 25, and higher scores indicated greater tumor burden. Associations of <jats:italic>RAS<\/jats:italic> mutations with disease\u2010free survival (DFS) and overall survival (OS) by the JSHBPS nomogram score were examined. Multivariable Cox proportional hazard regression models were used to estimate adjusted hazard ratios (HRs) and confidence intervals (CIs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>RAS<\/jats:italic> mutations were detected in 72 (33%) of the 218 patients. Multivariate analyses revealed that <jats:italic>RAS<\/jats:italic> mutations were independently associated with poor DFS (HR, 1.93; 95% CI: 1.20\u20133.10; <jats:italic>p<\/jats:italic>\u2009=\u2009.007) and OS (HR, 2.65; 95% CI: 1.59\u20134.71; <jats:italic>p<\/jats:italic>\u2009=\u2009.001) compared with wild\u2010type <jats:italic>RAS<\/jats:italic> with JSHBPS nomogram scores\u2009\u2264\u200910. However, in patients with scores\u2009\u2265\u200911, the association of <jats:italic>RAS<\/jats:italic> mutations with DFS or OS was not statistically significant (<jats:italic>p<\/jats:italic>\u2009&gt;\u2009.08).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>RAS<\/jats:italic> mutation status in combination with the JSHBPS nomogram may be useful for preoperatively identifying CRLM with high risk of recurrence and mortality after hepatectomy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jhbp.1389","type":"journal-article","created":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T06:54:37Z","timestamp":1698476077000},"page":"69-79","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["<i>RAS<\/i> mutation status in combination with the <scp>JSHBPS<\/scp> nomogram may be useful for preoperative identification of colorectal liver metastases with high risk of recurrence and mortality after hepatectomy"],"prefix":"10.1002","volume":"31","author":[{"given":"Toru","family":"Takematsu","sequence":"first","affiliation":[{"name":"Department of Gastroenterological Surgery, Graduate School of Life Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Mima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Graduate School of Life Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromitsu","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Graduate School of Life Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Kitano","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Graduate School of Life Sciences Kumamoto 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